Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans |
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| Authors: | Dr A Ceriello D Giugliano A Quatraro E Marchi M Barbanti P Lefèbvre |
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| Institution: | (1) Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Napoli;(2) Casa di Cura S. Rita, Centro di Diabetologia, Taranto;(3) Alfa Ricerche, Bologna, Italy;(4) Division of Diabetes, Nutrition and Metabolic Disorders, University of Liége, Liége, Belgium;(5) Viale Lincoln 4, I-81100 Parco Mecos, Caserta, Italy |
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| Abstract: | Summary In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus. |
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| Keywords: | Antithrombin III activity thrombin-antithrombin III complex fibrinopeptide A hyperglycaemia thrombin hyperactivity |
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