Regional Distribution of Choline Acetyltransferase and Acetylcholinesterase Activity in Baboon Brain |
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| Authors: | Yutaka Nakamura M.D. Rolf Hassler M.D. Kiyoshi Kataoka M.D. I. J. Bak Ph.D. J. S. Kim M.D. |
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| Affiliation: | Neurobiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt/M-Niederrad, West Germany;*National Musashi Hospital for Mental and Nervous Diseases, Tokyo;**Department of Physiology, Ehime University School of Medicine, Matsuyarna;***Department of Neurology, School of Medicine, The Center for the Health Sciences, Los Angeles, California 90024, USA |
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| Abstract: | (1) The activities of choline acetyltrans-ferase (ChAc) (EC 2.3.1.6) and acetyl-cholinesterase (AChE) (EC 3.1.1.7) were determined in about one hundred regions and subregions of baboon brain. The activities and distributions of these enzymes were in comparable to those found previously in the brains of other species. (2) ChAc activity was highest in the in-terpeduncular nucleus, where it was about twice that in the putamen, the region previously thought to be the richest in this enzyme. The caudate nucleus, the substantia perforata, the nucleus basalis, the central part of the amygdala and the oculomotor nucleus also had high activities. The activities in the cerebral and cerebellar cortex were less than one twentieth of that in the inter-peduncular nucleus. (3) The distribution of AChE activity was not entirely in parallel with that of ChAc. |
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