| 红景天苷对局灶性脑缺血再灌注大鼠突触超微结构的影响 |
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| 引用本文： | 刘晓梅,田国忠. 红景天苷对局灶性脑缺血再灌注大鼠突触超微结构的影响[J]. 解剖学研究, 2009, 31(5): 353-355 |
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| 作者姓名： | 刘晓梅 田国忠 |
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| 作者单位： | 1. 苏州卫生职业技术学院,江苏,苏州,215009
2. 佳木斯大学医学院,佳木斯,154007 |
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| 基金项目： | 苏州卫生职业技术学院基金，黑龙江省中医药管理局基金 |
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| 摘 要： | 目的研究红景天苷对局灶性脑缺血/再灌注损伤后突触结构和数密度的变化。方法采用线栓法制造大鼠大脑局灶缺血(2h)/再灌注模型(I/R模型),于灌注后1d、3d、7d、14d时间点断头取脑,电镜观察突触结构和数密度的变化。结果I/R模型组数目减少,7d降至最低,14d突触数目回升;突触结构随再灌注时间延长损伤加重,14d有所恢复;红景天组突触损害程度减轻,突触数目增加(P<0.05),突触数密度恢复的时间提早至7d。结论红景天苷可以减轻脑缺血再灌注后突触的损伤,易化突触可塑性。
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| 关 键 词： | 红景天苷 局灶性脑缺血/再灌注 突触 超微结构 |
Effect of Salidroside on synapse ultramicrostructure following focal cerebral ischemia/reperfusion in rats |
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| LIU Xiao-mei,TIAN Guo-zhong. Effect of Salidroside on synapse ultramicrostructure following focal cerebral ischemia/reperfusion in rats[J]. Anatomy Research, 2009, 31(5): 353-355 |
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| Authors: | LIU Xiao-mei TIAN Guo-zhong |
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| Affiliation: | LIU Xiao-mei,TIAN Guo-zhong. Suzhou Health College,Suzhou 215009 China |
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| Abstract: | Objective To explore the effects of salidroside on synapse ultramicrostructure following focal cerebral ischemia/reperfusion injury. Methods The model of the middle cerebral artery occlusion(2 h)/reperfusion in rats was prepared by using the intraluminal filament occlusion, The changes of synapse structure and density were observed by electron microscope at 1 d, 3 d, 7 d, 14 d after reperfusion. Results I/R control group The synapse densities were decreased after reperfusion, reached its lowest level at 3d.... |
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| Keywords: | Salidroside Focal cerebral ischemia/reperfusion Synapse Ultramicrostructure |
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