C-erbB-2 ,nm23 蛋白表达与结直肠癌浸润转移的相关性 |
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引用本文: | 许天文,陈道达,郑勇斌,连彦军. C-erbB-2 ,nm23 蛋白表达与结直肠癌浸润转移的相关性[J]. 华中科技大学学报(医学版), 2005, 34(2): 214-216 |
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作者姓名: | 许天文 陈道达 郑勇斌 连彦军 |
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作者单位: | 华中科技大学同济医学院附属协和医院普外科,武汉,430022 |
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摘 要: | 目的 探讨癌基因C- erbB- 2及转移抑制基因nm23在结直肠癌组织中的表达, 及其与局部浸润、淋巴结转移的关系。方法 采用免疫组化SP法, 检测66 例原发性结直肠癌患者手术切除的癌组织中C- erbB -2 及nm23 蛋白的表达。结果 C- erbB -2 蛋白阳性表达率与结直肠癌组织的分化程度无明显相关性(P>0 05), 与浸润深度、淋巴结的转移呈正相关( P<0. 05, P<0 .01)。nm23 蛋白在结直肠癌无淋巴结转移组中的阳性表达率显著高于有转移组(P<0. 01) , 其阳性表达率与结直肠癌淋巴结转移呈负相关。而且, 在淋巴结转移组中C -erbB -2 蛋白的阳性表达率与nm23 蛋白呈负相关。结论 C- erbB- 2 及nm23 蛋白的异常表达在结直肠癌的发生、发展和淋巴结转移中可能起重要作用。
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关 键 词: | 结肠肿瘤 直肠肿瘤 C-erbB-2蛋白 nm23蛋白 |
修稿时间: | 2004-01-08 |
Correlation between the Expression of C-erbB-2,nm23 Protein and Invasion, Lymph Node Metastasis of Human Colorectal Carcinoma |
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Abstract: | Objective To explore the relationship between the expressions of C-erbB-2,nm23 protein and local invasion,lymph node metastasis of colorectal carcinoma.Methods Using immunohistochemical technique SP method,the expression of C-erbB-2,nm23 protein was detected in 66 patients with human colorectal carcinoma.Results The positive expression rate of C-erbB-2 protein in colorectal carcinoma was not correlated with histological grade (P>0.05). There was a significant relationship between the expression of C-erbB-2 and the infiltrative depth,lymph node metastasis (P<0.05,P<0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than in the group with lymph node metastasis (P<0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of colorectal carcinoma. Furthermore,the negative correlation of the positive expression was found between C-erbB-2 protein and nm23 protein in the group with lymph node metastasis.Conclusion The abnormal expression of C-erbB-2,nm23 protein has an important significance in development and lymph node metastasis of colorectal carcinoma. |
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Keywords: | colorectal carcinoma C-erbB-2 protein nm23 protein |
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