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| 盐酸丁咯地尔对SD大鼠周围神经损害保护作用的初步实验研究 | |
| 引用本文： | 苏建华,章莉萍,唐金荣,肖杭,包德诚. 盐酸丁咯地尔对SD大鼠周围神经损害保护作用的初步实验研究[J]. 东南大学学报(医学版), 2005, 24(4): 253-255 |
| 作者姓名： | 苏建华 章莉萍 唐金荣 肖杭 包德诚 |
| 作者单位： | 1. 金坛市人民医院,神经内科,江苏,金坛,213200 2. 南京医科大学第一附属医院,神经内科,江苏,南京,210029 3. 南京医科大学,应用神经毒理研究所,江苏,南京,210029 |
| 基金项目： | 江苏省常州市卫生局资助项目(200217)。 |
| 摘 要： | 目的:探讨盐酸丁咯地尔对大鼠坐骨神经损害后恢复的影响。方法:以SD大鼠坐骨神经损伤建立周围神经损害动物模型,以坐骨神经传导速度和足趾间距为观察指标,考察盐酸丁咯地尔对坐骨神经损害后恢复的影响。结果:盐酸丁咯地尔高、低剂量组均能显著改善大鼠坐骨神经损害。结论:盐酸丁咯地尔对大鼠坐骨神经损害的恢复有积极的促进作用。 |
| 关 键 词： | 吡咯烷类治疗作用 周围神经系统疾病药物疗法 大鼠 SpragurDavoley |
| 文章编号： | 1671-6264(2005)04-0253-03 |
| 修稿时间： | 2004-09-30 |
Study on influence of buflomedil hydrochloride to sciatic nerve crush lesion in rats |
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| SU Jian-hua,ZANG Li-ping,TANG Jin-rong,XIAO Hang,BAO De-cheng. Study on influence of buflomedil hydrochloride to sciatic nerve crush lesion in rats[J]. Journal of Southeast Univ: Medical Sci Ed, 2005, 24(4): 253-255 | |
| Authors: | SU Jian-hua ZANG Li-ping TANG Jin-rong XIAO Hang BAO De-cheng |
| Affiliation: | SU Jian-hua 1,ZANG Li-ping 1,TANG Jin-rong 2,XIAO Hang 3,BAO De-cheng 1 |
| Abstract: | Objective Study on protective effect of buflomedil hydrochloride on sciatic nerve crush lesion in rats. Methods Sciatic nerve crush lesion mode are established in rats, then protection effect of buflomedil hydrochloride on sciatic nerve crush lesion was investigated by observing the conducting speed of crushed sciatic nerve as well as measuring interphalangeal distance of foot by foot print analysis. Results Buflomedil hydrochloride obviously recovered the sciatic crush lesion in rats. [WT5HZ]Conclusion Buflomedil hydrochloride can recover the sciatic nerve crush lesion. |
| Keywords: | pyrrolidines/therapeutic use peripheral nervous system diseases/drug therapy rats Sprague Dawley |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |