| 采用相似因子法评价不同因素对复方二甲双胍格列吡嗪双层缓释片体外释放的影响 |
| |
| 引用本文： | 欧阳德方,聂淑芳,孟晋,潘卫三. 采用相似因子法评价不同因素对复方二甲双胍格列吡嗪双层缓释片体外释放的影响[J]. 沈阳药科大学学报, 2006, 23(1): 1-5 |
| |
| 作者姓名： | 欧阳德方 聂淑芳 孟晋 潘卫三 |
| |
| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
| |
| 摘 要： | 目的考察不同因素对复方二甲双胍格列吡嗪双层缓释片(BT)体外释放的影响。方法采用相似因子法进行考察。结果各种因素对二甲双胍释放速率影响不大;HPMC的黏度、用量、填充剂的种类和搅拌速度对格列吡嗪释放速率有明显影响,填充剂的用量对格列吡嗪释放速率影响较小。结论相似因子法适合于缓控释制剂体外释放的评价。
|
| 关 键 词： | 二甲双胍 格列吡嗪 缓释片 相似因子 |
| 文章编号： | 1006-2858(2006)01-0001-05 |
| 收稿时间： | 2005-11-04 |
| 修稿时间： | 2005-11-04 |
Studies on the influencing factors on compound metformin-glipizide bilayer sustained-release tablets using the similarity factor |
| |
| OUYANG De-fang,NIE Shu-fang,MENG Jin,PAN Wei-san. Studies on the influencing factors on compound metformin-glipizide bilayer sustained-release tablets using the similarity factor[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(1): 1-5 |
| |
| Authors: | OUYANG De-fang NIE Shu-fang MENG Jin PAN Wei-san |
| |
| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
| |
| Abstract: | ObjectiveTo investigate the influencing factors on compound metformin-glipizide bilayer extended release tablets (BT).MethodsThe similarity factor was used.ResultsAll kinds of factors had little influence on metformin release.The viscosity and weight of hydroxypropylmethyl cellulose(HPMC),fillers and the stirring speed had significant influence on glipizide release,while weight of fillers had little effect on glipizide release.ConclusionsThe similarity factor is fit for evaluation of sustained or controlled release preparations. |
| |
| Keywords: | metformin glipizide sustained-release tablets similarity factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
