| 急性脑梗死血清高迁移率族蛋白B1水平的变化及意义研究 |
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| 引用本文： | 邢效如,陈长青,孙宗琴,陈丹丹,赵新春,武建宏,樊彦玲.急性脑梗死血清高迁移率族蛋白B1水平的变化及意义研究[J].实用心脑肺血管病杂志,2011,19(8):1279-1280. |
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| 作者姓名： | 邢效如 陈长青 孙宗琴 陈丹丹 赵新春 武建宏 樊彦玲 |
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| 作者单位： | 1. 天津市中国人民解放军第254医院神经内科,300142
2. 中国人民解放军第256医院中医科 |
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| 摘 要： | 目的通过检测急性脑梗死（acute cerebral infarction,ACI）患者血清高迁移率族蛋白B1（high mobil-ity group box 1,HMGB1）水平的变化,探讨HMGB1与ACI病情的关系。方法测定128例ACI患者、46名健康对照者血清HMGB1水平,观察比较ACI患者在不同病情、不同梗死面积时血清HMGB1水平的变化,对发病后48h病情发展变化进行评定,根据评分结果分为进展型与完全型脑梗死两组进行观察比较。结果 ACI患者血清HMGB1水平〔（9.05±2.03）μg/ml〕明显高于健康对照组〔（1.07±0.59）μg/ml〕,且HMGB1水平随神经功能缺损程度评分增高亦明显升高;进展性脑梗死患者血清HMGB1水平明显高于非进展性患者。结论 HMGB1一定程度上是预测ACI患者病情严重程度及进展的相关生化指标之一。
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| 关 键 词： | 急性脑梗死 高迁移率族蛋白B1 |
Clinical Significance of High Mobility Group Box 1 in Pationts with Acute Cerebral Infarction |
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| XING Xiao-ru,CHEN Chang-qing,SUN Zong-qin,et al..Clinical Significance of High Mobility Group Box 1 in Pationts with Acute Cerebral Infarction[J].Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2011,19(8):1279-1280. |
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| Authors: | XING Xiao-ru CHEN Chang-qing SUN Zong-qin |
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| Institution: | XING Xiao-ru,CHEN Chang-qing,SUN Zong-qin,et al.Department of Neurology,Chinese PLA 254 Hospital,Tianjin 300142,China |
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| Abstract: | Objective To investigate the change and its significance of high mobility group box 1(HMGB1)in patients with acute cerebral infarction(ACI).Methods The content of serum HMGB1 in 128 patients with ACI and 46 normal control were measured.The changes of HMGB1 were compared with patients of different pathogenetic condition and infarction areas.The disease progress were evaluated in 48 h after cerebral ischemic stroke.The patients were divided into progressive stroke and complete stroke.Results The level of HMGB... |
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| Keywords: | Acute cerebral infarction High mobility group box 1 |
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