RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects |
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| Authors: | Zhanwei Wang Hairong Dong Yuanyuan Fu Haixia Ding |
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| Affiliation: | (1) Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, 210029, China;(2) Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China;(3) Dental Research Institute, School of Stomatology, Nanjing Medical University, Nanjing, 210029, China;(4) Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China; |
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| Abstract: | RAD51 plays a key role in homologous recombination repair of double-stranded DNA breaks which may cause chromosomal breaks and genomic instability. We performed a meta-analysis of 9 epidemiological studies involving 13,241 cases and 13,203 controls that examined the association between RAD51 135G>C polymorphism and breast cancer. No significant association of RAD51 135G>C polymorphism with breast cancer was found in overall and European populations. However, after the studies which did not fulfill Hardy–Weinberg equilibrium were excluded, we observed an overall significant increased breast cancer risk (for the recessive model CC vs. GG/CG: OR = 1.35, 95% CI = 1.05–1.74, P heterogeneity = 0.06). In summary, our meta-analysis suggested the RAD51 135G>C polymorphism may contribute to breast cancer susceptibility. |
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