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| Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus | |
| 作者单位： | DU Jian-ling(Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China;Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China);SUN Chang-kai(Institute of Brain Disorders and Key Lab for Brain Disorders of Liaoning Province,Dalian Medical University,Dalian,Liaoning 116044,China);L(U) Bo,MEN Li-li,YAO Jun-jie(Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China);AN Li-jia(Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China);SONG Gui-rong(Department of Health Statistics,Dalian Medical University,Dalian,Liaoning 116044,China) |
| 基金项目： | 国家自然科学基金，National Key Research Project for the Tenth Five Year Plan，Key Research Project of Liaoning Province Bureau of Science and Technology |
| 摘 要： | Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）. Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis. |
| 关 键 词： | 血清抗体A 胰岛素抗性 2型糖尿病 治疗方法 |
Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus |
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| Authors: | DU Jian-ling SUN Chang-kai L Bo MEN Li-li YAO Jun-jie AN Li-jia SONG Gui-rong |
| Institution: | 1. Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China;Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China 2. Institute of Brain Disorders and Key Lab for Brain Disorders of Liaoning Province,Dalian Medical University,Dalian,Liaoning 116044,China 3. Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China 4. Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China 5. Department of Health Statistics,Dalian Medical University,Dalian,Liaoning 116044,China |
| Abstract: | Background Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats (Psammomys obesus, Israeli sand rat) and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM), and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level.Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction (PCR), Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay (ELISA).Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis. |
| Keywords: | tanis/SelS serum amyloid A insulin resistance type 2 diabetes mellitus |
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