| 三种蒽环类抗肿瘤药物对K562/A02细胞体外抑制作用 |
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| 引用本文： | 肖希斌, 谢兆霞, 陈宏. 三种蒽环类抗肿瘤药物对K562/A02细胞体外抑制作用[J]. 中国肿瘤临床, 2005, 32(7): 407-408. |
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| 作者姓名： | 肖希斌 谢兆霞 陈宏 |
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| 作者单位： | 中南大学湘雅医院血液科, 长沙市 410008 |
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| 摘 要： | 目的: 比较表阿霉素,柔红霉素和吡喃阿霉素对多药耐药细胞株K562/A02体外增殖的抑制作用. 方法: 利用MTT观察7.5～60μg/ml的表阿霉素或柔红霉素或吡喃阿霉素处理K562/A02细胞后细胞增殖的变化. 结果: 吡喃阿霉素剂量逐渐增大时,抑制率逐渐增强(P<0.05).吡喃阿霉素组对K562/A02细胞的抑制率较相同剂量表阿霉素组或柔红霉素组抑制率显著增加(P<0.01). 结论: 相同剂量的吡喃阿霉素较表阿霉素或柔红霉素有更强的抑制多药耐药细胞株K562/A02细胞的作用.
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| 关 键 词： | 表阿霉素 柔红霉素 吡喃阿霉素 K562/A02细胞 |
| 文章编号： | 1000-8179(2005)07-0407-02 |
| 收稿时间： | 2004-10-28 |
| 修稿时间： | 2005-01-04 |
The Effect of Three Anthracycline Antineoplastic Drugs on K562/A02 Cell Line Proliferation in vitro |
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| Xiao Xibin, Xie Zhaoxia, Chen Hong. The Effect of Three Anthracycline Antineoplastic Drugs on K562/A02 Cell Line Proliferation in vitro[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(7): 407-408. |
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| Authors: | Xiao Xibin Xie Zhaoxia Chen Hong |
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| Affiliation: | Deportment of hematology, Xaungyu hospata, Central South Unaversaty, Chungsha |
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| Abstract: | Objective :To compare the effect of three kinds of anthracycline antineoplastic drugs cell line proliferation in vitro. Methods :MTT method 7.5 60 N.,g/ml cell line was was used to observe the alteration of the proliferation of K562/A02 cell line treated with Pirarubicin. Results :The inhibiting rate on K562/A02 Pharmorubicin or Daunorubicin or increased when the dose of Pirarubicin got higher candy higher than (P<0.05). The inhibition rate on K562/A02 cell line of Pirarubicin group was signifithat of the sa17e dose of Pharmorubicin or Daunorubicin (P<0.01). Conclusions :Pirarubicin has stronger inhibitive abilityon K562/A02 cell line proliferation than the same concentrationof Pharmorubicin or Daunorubicin in vitro. |
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| Keywords: | Pharmorubicin Pirarubicin Daunorubicin K562/A02 cell |
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