Immunologic studies in patients with dilated cardiomyopathy] |
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| Authors: | S Vogt P Ewers H Goos B Krosse M L?be M Ladusch K Seim M Wolff |
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| Affiliation: | Klinik für Herz- und Gef?sschirurgie, Sektion Biowissenschaften der Universit?t Leipzig. |
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| Abstract: | In 10 cases of dilated cardiomyopathy the HLA-loci (A, B, C, DR) and marker expression on lymphocytes were studied. In this group the T4/T8-ratio was decreased and interleukin-2-expression was increased in relation to normals or patients with chronic coronary heart disease, respectively. 9 patients had the HLA-A1 or HLA-A2-locus in their siblings. In correlation analysis between immunological and hemodynamic parameters a good correlation of the number of NK-cells to the ejection fraction (r = 0.79) and negative correlation of helpercells (CD4) to the cardiac output were found (r = -0.80). The results of this attempt suggest an immunological pathogenesis of the dilated cardiomyopathy. |
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