芎麻汤不同提取物对小鼠偏头痛模型的影响

目的:观察芎麻汤不同提取物治疗偏头痛的药理作用。方法:采用小鼠皮下注射1 mg.kg-1利血平致小鼠偏头痛模型、醋酸致小鼠扭体模型,昆明小鼠随机分为阿米替林组(0.033 g.kg-1)、芎麻汤水提液组(1.4,5.6 g.kg-1)、芎麻汤醇提组(1.4,5.6 g.kg-1)、芎麻汤挥发油组(1.4,5.6 g.kg-1),连续给药7 d,观察芎麻汤水提液,挥发油、醇提液对偏头痛模型小鼠血清5-羟色胺(5-HT)含量及镇痛作用的影响。结果:芎麻汤水提液(5.6 g.kg-1)能明显升高利血平化低5-HT小鼠模型血清中5-HT的含量(P<0.01),芎麻汤挥发油(1.4,5.6 g.kg-1)能明显延长冰醋酸致小鼠扭体潜伏期及减少扭体次数。结论:芎麻汤水提液对偏头痛小鼠模型有一定的作用,芎麻汤挥发油具有一定的镇痛作用。

Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model

Objective : To observe effects of different extracts from Xiongma decoction on migraine. Method : The mice migraine model was induced by, reserpin and acetic acid was used to induce mice writhing model. Mice were injected 1 mg·kg^-1 reserpine to induce migraine model. Mice were randomly divided into amitriptyline group (0.033 g·kg^-1), extract group of Xiongma decocotion (1.4, 5.6 g·kg^-1), alcohol extract group of Xiongma decoction(1.4, 5.6 g·kg^-1), volatile oil group (1.4, 5.6 g·kg^-1), which were orally given for 7 days. The level of 5-HT and analgesic effect were observed. Result : The extracts from Xiongma decoction significantly increased 5-HT level (P <0.01). Volatile oil extract can significantly prolong the incubation period of acetic acid induced writhing and twisting frequency (P <0.05). Conclusion : Extracts of Xiongma decoction have a certain effect on mice migraine model and an analgesic effect.