泛耐药鲍曼不动杆菌交叉感染的防控策略

目的总结呼吸重症监护病房（RICU）防控泛耐药（PDR）鲍曼不动杆菌交叉感染的经验，探讨泛耐药鲍曼不动杆菌以及其他泛耐药株交叉感染防控的新思路及有效方法。方法采用脉冲场凝胶电泳（PFGE）方法对分离自RICU的泛耐药鲍曼不动杆菌进行分子分型，提出“降阶梯防控策略”并实施。结果自RICU4例患者检出的PDR鲍曼不动杆菌PFGE图形一致，存在交叉感染；采取降阶梯防控措施，未再有其他患者感染PDR鲍曼不动杆菌。结论4例RICU患者存在PDR鲍曼不动杆菌交叉感染，采取“降阶梯防控策略”对控制泛耐药鲍曼不动杆菌以及其他泛耐药株交叉感染有重大意义。

The prevention and control of pan-drug resistant acinetobacter baumanii cross-infection

Objective To summarize the experience of prevention and control of pan-drug resistant acine- tobacter baurnanii cross-infection,in order to create a novel thought of the effective prevention and control of related PDR pathogens,including A.baumanii.Methods Pulsed-field gel electrophoresis(PFGE) was applied to analyze the 5 PDR A.baumanii strains isolated from 4 patients in RICU.According to the hazard of acquiring cross-infection,we adopted"De-escalation prevention and control strategy"to RICU patients.Results PFGE analysis showed 5 PDR A.baumanii were identical,which confirmed cross-in- fection between the 4 patients.There was no more patient acquiring PDR A.baumanii infection in RICU anymore.Conclusion"De-escalation prevention and control strategy"has important meaning in the pre- vention and control of all related PDR pathogens including A.baumanii.