卡托普利对接触振动家兔血管内皮活性物质的影响

目的探讨小剂量卡托普利对接触振动家兔血管内皮活性物质的影响及其意义。方法将家兔分为接振对照组、实验组和无接振对照组,实验组与接振对照组分别进行强度10m/s2的接触振动实验。实验组在第11天起给予小剂量卡托普利。于接触振动前、接触振动后10d、20d、30d对各组家兔进行血浆内皮素(ET)和一氧化氮(NO)浓度的测定与分析。结果与接触振动前比较,接触振动20d、30d接振对照组血浆NO浓度显著下降(P<0.01)、ET浓度显著升高;实验组、无接振对照组在接触振动前后血浆NO、ET浓度差异无显著性。结论小剂量卡托普利可通过影响血管内皮活性物质,对接触振动家兔外周血管功能产生一定的保护作用。

The effects of low dose captopril on the vascular endothelial active substance in rabbits exposed to local vibration

Objective To explore the effects of low dose captopril on the peripheral vascular function in rabbits tested by local vibration.Methods Rabbits were divided into three groups randomly, pure-exposed vibration control group, captopril intervention group and control group. The concentrations of plasma endothelin(ET) and nitric oxide(NO) were measured and analyzed in each group before the test and on the 10th, 20th and 30th day after the test.Results Compared with the captopril intervention group and the control group on the 20th and 30th day of vibration exposure, there was a significant increasing tendency in plasma ET and a significant decreasing tendency in plasma NO in pure-exposed vibration control group (P<0.01), but there was no obvious difference in captopril intervention group and control group themselves before and after the exposure. Conclusion Captopril has certain protection effect on peripheral vascular function of the rabbits exposed to local vibration.