Osteomalacia and celiac disease: Response to 25-hydroxyvitamin D

In this 54 year old woman with celiac disease, osteomalacia developed while she was on a gluten-free diet which had caused regression of her steatorrhea. She was not responsive to large doses of parenterally administered dihydrotachysterol and calcium, but she was responsive to the oral administration of 25-hydroxyvitamin D₃ (25-OHD₃). The data suggest that 25-OHD₃ Is the treatment of choice for patients with vitamin D deficiency due to intestinal malabsorption.