丹参抗脑缺血在神经细胞、分子及递质水平的作用机制研究进展

目的为丹参抗脑缺血的药理及临床研究提供理论依据。方法查阅1989-2006年清华同方数据库,回顾分析丹参在神经细胞、分子及递质水平的脑缺血保护作用机制的研究报道。结果丹参抗脑缺血在神经细胞、分子及递质水平的作用机制主要有:通过抑制缺血区小胶质细胞的活化、抑制ICAM-1的表达等降低神经细胞的损伤;通过下调ICE表达、上调bcl-2蛋白的表达等抑制神经细胞的凋亡;通过减少NO合成、抑制EAA释放等影响神经递质水平;通过抑制ET-1表达、调节TXA2-PGI2平衡等影响血管相关活性物质的表达。结论丹参可从降低神经细胞的损伤、抑制神经细胞的凋亡、影响神经递质及血管活性物质的表达等多个方面起到脑缺血保护作用。

Study progress of mechanism of radix salviae miltiorhizae in Anti-brain ischemic injury

Objective To analyze the protective mechanism of RSM(Rradix salviae miltiorhizae) in brain ischemic injury at the level of neural cell,molecular and transmitter,and to provide theoretical evidence for its experimental and cminical research.Methods Searching the recent research of the protective mechanism of RSM in brain ischemic injury from 1989 to 2006 retrospectively by CNKI.Results Firstly,RSM has neural cell damage reduction which is based on inhibiting microglial activation and the express of ICAM-1 and so on.Secondly,RSM can inhibit the apoptosis of neural cell,which is increased with bcl-2 and decreased with ICE,et al.Thirdly,RSM can effect neural transmitters' level by reducing the Saponin of NO and inhibiting the EAA's liberation and so on.At last,RSM can also affect the express of vas active substance through inhibiting ET-1's expression and regulating the balance of TXA2-PGI2.Conclusion RSM has the protective actions against cerebral ischemic by reducing the injury of neural cell,and regulating the expression of cyclins,neurotransmitter and vasoactive,and so on.