高原红细胞增多症动脉粥样硬化危险因素分析

目的检测高原红细胞增多症(HAPC)有关血脂、血压、体重指标并分析其与动脉粥样硬化的关系。方法在海拔2800 m青海格尔木地区选择HAPC患者86例和健康对照人群200例,清晨空腹状态下检测血压、体重、心率等生理参数及血脂指标,并进行比较分析。结果 HAPC组较对照组:(1)血TG、LDL升高,HDL、ApoA1降低,动脉硬化指数增高及ApoA1/ApoB比值降低,差异具有显著性(P<0.05);高甘油三酯血症、高胆固醇血症、混合型高脂血症、低高密度脂蛋白血症的比例较对照组明显增高,其中高甘油三酯血症的检出率高于其他血脂增高类型,差异具有显著性(P<0.05)。(2)体重、体质指数、心率较对照组明显增高,肥胖、高血压的检出率较对照组明显增高,且高血压以舒张压增高为多见,差异具有显著性(P<0.05)。结论 HAPC具有血脂紊乱、高血压、肥胖这三种重要的动脉粥样硬化高危因素,提示其发生动脉粥样硬化及其相关疾病的危险性增高。

The Study of Arteriosclerosis Risk Factors in High Altitude Polycythemia

Aim To detect the level of blood lipid,blood pressure and weight index and explore the relationship between those three indexes and Arteriosclerosis in High Altitude Polycythemia(HAPC).Methods The physiology parameters such as blood pressure,weight,heart rate and blood lipid detection were performed at the early morning empty stomach condition in 86 HAPC patients and 200 healthy people in Geermud,Qinghai,2800 meters above sea level,then the results were analyzed.Results(1)The level of TG,LDL and arteriosclerosis index were higher,while the level of blood HDL,ApoA1 and the ratio of ApoA1/ ApoB were lower in HAPC group than the control group.It has the significant difference(P<0.05).The relevance ratio of hypertriglyceridemia,hypercholesterolemia,combined hyperlipidemia,hypo-high-density lipoprotein cholesterolemia,were higher in HAPC group than the control group.The relevance ratio of hypertriglyceridemia was the highest in those high blood lipid group.It has the significant difference(P<0.05).(2)The level of weight,BMI and heart rate were higher in HAPC group than the control group.The relevance ratio of obesity and high bood pressure were higher in HAPC group than the control group.Hypertension is more common with increased diastolic blood pressure.It has the significant difference(P<0.05).Conclusion HAPC has those three atherosclerosis risk factors such as blood pressure,obesity,lipid disorders.It suggests the increased risk of atherosclerosis and associated diseases in HAPC.