中国15岁以上人群结核病发病危险因素meta分析

目的 综合评价我国结核病发病危险因素,为展开有效的健康干预措施提供依据。 方法 以“结核病”、“危险因素”等为检索词,通过Pubmed/Medline、EMBASE、CNKI等数据库检索相关文献,按纳入标准和排除标准筛选文献,提取相关数据,使用RevMan 5.3软件对数据进行meta分析。 结果 共纳入文献22篇,研究对象11 004名。各相关因素合并后的OR值及95%CI分别为结核(tuberculosis, TB)接触史3.13(2.73~3.60)、低体质指数(body mass index, BMI)2.93(1.78~4.82)、吸烟1.72(1.39~2.12)、劳动强度大2.29(1.80~2.90)、饮酒1.29(0.93~1.79)、经济收入低1.73(1.41~2.12)、人际交往多1.96(1.65~2.33)、居住条件差1.16(1.10~1.23)、负性生活事件1.92(1.09~3.39)、TB认知差2.07(1.68~2.54)、卡痕0.35(0.25~0.50)、卡介苗接种史0.60(0.47~0.76)、文化程度高0.58(0.51~0.65)、体育锻炼0.35(0.14~0.87)、家庭有结核病人2.12(1.54~2.93)。 结论 TB接触史、低BMI、吸烟、劳动强度大、经济收入低、人际交往多、负性生活事件、TB认知差、家庭有结核病人等因素与结核病发病密切相关,应针对以上因素,在TB高危人群中开展有效的健康干预。

Meta-analysis on risk factors related to the incidence of tuberculosis in Chinese population aged 15 years and above

Objective To synthetically evaluate the risk factors associated with the incidence of tuberculosis in China so as to provide evidence for conducting effective intervention measures. Methods We retrieved the studies by searching risk factor, tuberculosis and other terms in Pubmed/Medline, EMBASE, CNKI and other databases, screened the studies according to the inclusion and exclusion criteria, and then extracted the related data. Review Manager 5.3 software was used to perform meta-analysis. Results Twenty-two studies and 11,004 objects were included in this study. Meta-analysis showed that factors as tuberculosis contact history(pooled OR values, OR=3.13, 95%CI:2.73-3.60), low body mass index (BMI) (OR=2.93, 95%CI:1.78-4.82), smoking(OR=1.72, 95%CI:1.39-2.12), high labor intensity(OR=2.29, 95%CI:1.80-2.90), drinking(OR=1.29, 95%CI:0.93-1.79), low income(OR=1.73, 95%CI:1.41-2.12), much interpersonal communication(OR=1.96, 95%CI:1.65-2.33), poor housing conditions(OR=1.16, 95%CI:1.10-1.23), negative life events(OR=1.92, 95%CI:1.09-3.39), low awareness of tuberculosis(OR=2.07, 95%CI:1.68-2.54), BCG (bacille Calmette-Guerin) scar(OR=0.35, 95%CI:0.25-0.50), BCG vaccination history(OR=0.60, 95%CI:0.47-0.76), high education level(OR=0.58, 95%CI:0.51-0.65), physical exercise(OR=0.35, 95%CI:0.14-0.87), families with tuberculosis patients (OR=2.12, 95%CI:1.54-2.93)were associated with the incidence of tuberculosis. Conclusions The factors as tuberculosis contact history, low BMI, smoking, high labor intensity, low income, much interpersonal communication, negative life events, low awareness of tuberculosis and families with tuberculosis patients are closely related to the incidence of tuberculosis; and hence, effective health intervention against the above-mentioned factors should be carried out in the high-risk population of tuberculosis.