多囊卵巢综合征与子宫内膜癌罹患风险系统评价

目的 探索多囊卵巢综合征(PCOS)和子宫内膜癌(EC)的相关性,以确定PCOS是否会增加EC的患病风险。方法 遵循meta分析方法,检索Pubmed、Cochrane、Medline、万方、CNKI等数据库,收集有关多囊卵巢综合征与子宫内膜癌发病风险的研究文献,利用纽卡斯尔-渥太华量表(Newcastle-Ottawa-Scale,NOS)对纳入文献进行质量评价,并应用STATA 12.0软件计算纳入的病例对照研究中的比值比(OR)及95%置信区间(95%CI),对纳入的队列研究进行系统评价。 结果 共检索出442篇文献,最终纳入7篇符合标准的文献(4篇病例对照研究,3篇队列研究)。病例对照研究的Meta分析表明,PCOS与EC并无显著相关性(OR=1.82,95%CI=0.84~3.93,I²=64.6%,P=0.037)。结论 目前证据提示PCOS与EC发病风险相关性并不显著,但由于两者关系较复杂,影响因素较多,建议进行设计更为合理的临床研究。

Polycystic ovary syndrome in relation to risk of endometrial cancer:a systematic review of the literature

Objective To explore the correlation between polycystic ovarian syndrome (PCOS) and endometrial cancer (EC) so as to determine whether PCOS might increase the risk of developing EC. Methods We searched Pubmed, the Cochrane Library, Medline, Wanfang, CNKI and other databases, and collected the literature about PCOS in relation to the risk of developing EC. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the literature. A meta-analysis was performed to calculate odds ratio (OR) and 95% confidence interval (95%CI) of the included case-control studies by using STATA 12.0 software, and a systematic review of cohort studies were also conducted.Results A total of 442 studies were retrieved, and finally 7 eligible studies (including 4 case-control studies and 3 cohort studies) were included. Meta analysis of case-control studies showed that there was no significant correlation between PCOS and EC (OR=1.82, 95%CI=0.84-3.93, I²=64.6%, P=0.037). Conclusions No significant correlation is found between PCOS and the risk of developing EC based on the current evidence. But the relationship between them is complex and is affected by many factors; and hence, further better-designed studies are still required.