| TLR4基因多态性与疾病易感性的研究进展 |
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| 引用本文： | 刘晓聪,沈关心,朱慧芬,陈琰琰,姜素华.TLR4基因多态性与疾病易感性的研究进展[J].农垦医学,2012,34(3):258-262. |
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| 作者姓名： | 刘晓聪 沈关心 朱慧芬 陈琰琰 姜素华 |
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| 作者单位： | 1. 石河子大学医学院病原生物学与免疫学教研室,新疆石河子,832002
2. 华中科技大学同济医学院免疫系,武汉,430000 |
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| 摘 要： | Toll样受体是近年来发现的跨膜信号传递受体,作为一种重要的模式识别受体(PRRs)在多种疾病中起着重要的作用.基因多态性影响机体对疾病的遗传易感性.TLR4作为跨膜受体与多种疾病有着密切的联系,越来越多数据表明,TLRs单核苷酸多态性(SNPs)与多种疾病遗传易感性相关,本文就TLR4 SNPs与多种疾病的遗传易感性之间相关性进行综述.
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| 关 键 词： | TLR4 单核苷酸多态性 疾病 |
Advancement of the Relationship between Gene Polymorphisms of Toll-Like4 Receptors and Diseases |
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| LIU Xiao-cong
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SHEN Guan-xin
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Zhu Hui-fen
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Chen Yan-yan
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JIANG Shu-hua.Advancement of the Relationship between Gene Polymorphisms of Toll-Like4 Receptors and Diseases[J].Agricultural Reclamation Medicine,2012,34(3):258-262. |
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| Authors: | LIU Xiao-cong SHEN Guan-xin Zhu Hui-fen Chen Yan-yan JIANG Shu-hua |
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| Institution: | LIU Xiao-cong1,SHEN Guan-xin2,Zhu Hui-fen2,Chen Yan-yan1,JIANG Shu-hua1(1.Department of Pathogenic Biology and Immunology,Shihezi University School of Medicine,Xinjing Shihezi,832002; 2.Department of Immunology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430000) |
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| Abstract: | Objective: Toll like receptors(TLRs) were identified as transmembrane signal transduction proteins in recent years,and single nucleotide polymorphisms of TLR genes are associated with the inflammatory responses and susceptibility to many diseases.Most studies have indicated that single nucleotide polymorphisms of TLR4 has close correlations with the pathogenesis of many diseases.In this review,we summarized the relationship between genetic polymorphisms of TLR4 and several disease. |
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| Keywords: | TLR4 SNPs disease |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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