盐酸法舒地尔治疗老年糖尿病患者颈部血管斑块病变疗效观察

目的:了解老年2型糖尿病患者颈部血管病变状态,探讨Rho激酶抑制剂盐酸法舒地尔的治疗疗效。方法:应用彩色多普勒检查92例老年2型糖尿病患者颈部动脉,主要超声参数与健康老年人比较;72例血管斑块病变患者分为2组,分别应用阿司匹林+盐酸川芎嗪、阿司匹林+盐酸法舒地尔治疗,超声检查观察疗效。结果:老年糖尿病患者颈部动脉内膜增厚,血管内膜不光滑,壁上钙化斑块形成,且血流量相应减少。阿司匹林+法舒地尔治疗组患者治疗后颈部血管血流峰值速度及流量明显改善(P<0.01或P<0.05),显著优于盐酸川芎嗪组。结论:老年2型糖尿病患者易并发颈部血管病变;应用阿司匹林联合盐酸法舒地尔治疗可明显减少颈部血管的斑块病变,改善血管内血流峰值速度及流量,对预防糖尿病脑卒中的发生有重要意义。

The Effective Observation of Hydrochloric Fasudil In Treatment of Diabetes Mellitus Patient with Cervical Atherosclerosis Plaque

Objective:To investigate cervical atherosclerosis plaque in the aged with type 2 diabetes mellitus and explore the effectiveness of Rho-kinase inhibitor hydrochloric Fasudil on these patients.Methods:Compared with the normal aged,the main ultrasonic parameters of carotid artery in 92 elderly patients with type 2 diabetes mellitus were analyzed by color Doppler.92 cases of patients with cervical atherosclerosis plaque were randomly divided into trial group and control group.Aspirin and Ligustrazine Hydrochloride were applied to treatment in control group.Aspirin and Fasudil were applied to treatment in trial group.Doppler ultrasound was used to observe the above results.Results:The ultrasonic Doppler examination showed that the inner-diameter of carotid artery in elderly patients with diabetes mellitus was enlarged,intima was rough,the walls had some plaque and the blood was reduced.The improvement of the maximal systolic velocity and the blood volume in cases treated groups by Aspirin and hydrochloric Fasudil was observed significantly higher(P<0.01 or P<0.05) than that of Aspirin and Ligustrazine Hydrochloride.Conclusion:The incidence of cervical atherosclerosis plaque is usually high in aged with type 2 diabetes mellitus.The application of Aspirin and hydrochloric Fasudil might help to decrease the plaque of cervical vascular significantly.The improvement of the maximal systolic velocity and the blood volume has an actively clinical significance for preventing stroke in patient with diabetes.