乌司他丁对急性百草枯中毒的疗效观察

目的探讨乌司他丁对急性百草枯中毒的治疗效果。方法选择2010年9月-2012年2月收治的急性百草枯中毒患者53例为研究对象,分为常规治疗组和乌司他丁组。乌司他丁组在常规治疗基础上加用乌司他丁注射液治疗。比较两组患者发生肺纤维化、多器官功能障碍综合征(MODS)及病死率之间的差异。结果与常规治疗组相比,乌司他丁组发生肺纤维化、MODS的人数少,差异有统计学意义(P<0.05);乌司他丁组病死率低于常规治疗组,差异有统计学意义(P<0.05)。结论乌司他丁在治疗急性百草枯中毒时能够有效改善脏器功能、降低肺纤维化及MODS的发生率,改善预后,降低病死率,是临床上急性百草枯中毒的有效治疗方法之一。

Curative Effects of Ulinastatin on Acute Paraquat Poisoning

Objective To evaluate the value of Ulinastatin in the treatment of acute paraquat poisoning.Methods Fifty three patients with acute paraquat poisoning who were admitted to our hospital from September 2010 to February 2012 were divided into the conventional therapy group and Ulinastatin group.The Ulinastatin group accepted Ulinastatin injection on the basis of conventional therapy.The difference in the pulmonary fibrosis,multiple organ dysfunction syndromes(MODS) and mortality between the conventional therapy group and Ulinastatin group were comnpared.Results The cases of the pulmonary fibrosis and MODS in the Ulinastatin group were less than that in the conventional therapy group,and the difference was statistically significance(P<0.05).The fatality rate in the Ulinastatin group was lower than the conventional treatment group and the difference was statistically significant(P<0.05).Conclusion Ulinastatin combined with conventional therapy can improve organ function,and reduce the incidence of pulmonary fibrosis and MODS and mortality in the treatment of acute paraquat poisoning,which is one of the effective treatment of acute paraquat poisoning in clinical.