丁苯肽治疗血管性痴呆疗效观察 |
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引用本文: | 张蕾.丁苯肽治疗血管性痴呆疗效观察[J].中华全科医学,2012,10(10):1528-1529. |
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作者姓名: | 张蕾 |
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作者单位: | 安徽省宿州市立医院神经内科三病区 |
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摘 要: | 目的研究丁苯酞对血管性痴呆(VD)患者认知功能的影响、生活能力的改善及安全性。方法选择临床明确诊断为VD的患者62例,随机分为对照组和治疗组,对照组予以常规口服阿司匹林、吡拉西坦治疗,治疗组在以上治疗基础上加用丁苯酞长期口服,以60 d为一个评定周期,两组患者在治疗前及治疗60 d分别对其进行简易智能状态量表(MMSE)和日常生活能力表(ADL)评分,并进行比较,同时评价丁苯肽软胶囊的药物不良反应。结果两组治疗后的MMSE及ADL评分较治疗前均有显著提高(P<0.01),与对照组相比,治疗组治疗后MMSE及ADL评分较对照组改善更为明显,两组治疗后评分比较差异具有统计学意义(P<0.05)。结论丁苯肽联合吡拉西坦治疗血管性痴呆临床有效,能显著改善VD患者的认知功能,且不良反应少。
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关 键 词: | 血管性痴呆 丁苯肽 MMSE ADL |
The Clinical Research of Combination of Butylphthalide and Piracetam in the Treatment of Patients with Vascular Demetia |
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Authors: | ZHANG Lei |
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Institution: | ZHANG Lei.The Third Department of Neurology,The Municipal Hospital of Suzhou,Suzhou 234000,Anhui,China |
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Abstract: | Objective To research the curative effect of butylphthalide in treating vascular dementia,the improvement of the ability of living and its safety.Methods 62 cases with VD were randomly divided into 2 groups: control group and butylphthalide group;MMSE and ADL scores were applied to patients in both groups before treatment and after being treated for 60 days,the results were compared;the evaluation of the side-effect of butylphthalide was made at the same time.Results The scores of MMSE and ADL of the patients in both groups after treatment were much higher than those before treatment(P<0.01);the scores of butylphthalide group after treatment were improved much more obviously than those of control group(P<0.01),the difference between the 2 groups was of significance(P<0.05).Conclusion Butylphthalide was of definite curative effect and of less side effect in treating vascular dementia. |
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Keywords: | Vascular dementia Butylphthalide MMSE ADL |
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