| 蒲黄活性部位的药效学筛选研究 |
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| 引用本文： | 陈佩东 严辉 丁安伟. 蒲黄活性部位的药效学筛选研究[J]. 南京中医药大学学报, 2006, 22(5): 302-303 |
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| 作者姓名： | 陈佩东 严辉 丁安伟 |
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| 作者单位： | 南京中医药大学药学院,江苏,南京,210046;南京中医药大学药学院,江苏,南京,210046;南京中医药大学药学院,江苏,南京,210046 |
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| 基金项目： | 国家中医药管理局资助项目 |
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| 摘 要： | 目的确定生蒲黄、炒蒲黄、蒲黄炭止血作用主要活性部位。方法对生蒲黄、炒蒲黄、蒲黄炭按不同溶剂极性及不同化学成分类型提取,以小鼠的止血时间为筛选指标对各部位进行筛选。结果蒲黄及炮制品的乙酸乙酯部位、正丁醇部位、总黄酮部位可明显缩短小鼠凝血时间。结论初步认为总黄酮部位为生蒲黄及其饮片止血作用的主要活性部位。
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| 关 键 词： | 生蒲黄 炒蒲黄 蒲黄炭 活性部位 药效学 |
| 文章编号： | 1000-5005（2005）05-0302-02 |
| 收稿时间： | 2006-05-18 |
| 修稿时间： | 2006-06-20 |
Pharmaceutical Screening of Active Parts of Pollen Typhae |
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| CHEN Pei-dong,YAN Hui,DING An-wei. Pharmaceutical Screening of Active Parts of Pollen Typhae[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2006, 22(5): 302-303 |
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| Authors: | CHEN Pei-dong YAN Hui DING An-wei |
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| Affiliation: | Pharmacology College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210029, China |
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| Abstract: | OBJECTIVE To determine the main active parts of crude Pollen Typhae,parched Pollen Typhae and carbonized Pollen Typhae.METHOD Extraction was conducted according to different dissolvent heteropolarity and different chemical components and screening conducted with hemostatic time in mice as the index.RESULT The acetic ether portion,n-butanol portion and total flavonoids portion of Pollen Typhae could markedly shorten the coagulate time in mice.CONCLUSION It is preliminarily believed that the total flavonoids portion is the active part of the analgesic effect of crude Pollen Typhae. |
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| Keywords: | crude Pollen Typhae parched Pollen Typhae carbonized Pollen Typhae active part pharmacodynamics |
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