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A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression |
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| Authors: | M Marttila J J skel inen R J rvi M Romanov E Miettinen P Sorri U Ahlfors and M Zivkov |
| Institution: | a Seinäojoki Hospital, Clinic of General Hospital Psychiatry, Hanneksenrinne 7, SF-60220, Seinäjoki, Finland b University Hospital of Kuopio, Psychiatric Clinic, PL 1777, 70101, Kuopio, Finland c Turku Mental Health Centre, Yliopistonkatu 24 A 4, SF-20100, Turku, Finland d Jyväskylä Mental Health Centre, Gummeruksenkatu 7A, SF-40100, Jyväskylä, Finland e Mikkeli Central Hospital, Department of General Hospital Psychiatry, SF-50100, Mikkeli, Finland f Tampere University Hospital, P.O. Box 2000, SF-33521, Tampere, Finland g Hesperia Hospital, Välskärinkatu 2, SF-00260, Helsinki, Finland h Medical Services Department, N.V. Organon, P.O. Box 20, 5340 BH, Oss, The Netherlands |
| Abstract: | One hundred and sixty-three patients with major depression were randomly assigned to treatment with mirtazapine or doxepin for 6 weeks in a double-blind clinical trial. Initially, patients received mirtazapine 20 mg/day or doxepin 75 mg/day, dosages were then titrated up to a maximum of 60 mg/day and 300 mg/day, respectively. Both drugs produced considerable improvement in depressive symptoms with no statistically significant differences between the two patient groups. In the mirtazapine group only two patients prematurely terminated the study due to adverse drug experiences, as compared to six in the doxepin-treated group. Moreover, doxepin-treated patients complained more frequently of dry mouth and movement disorders. In conclusion, mirtazapine is an effective treatment for major depression and appears to offer advantages in tolerability over doxepin. |
| Keywords: | Mirtazapine Doxepin Major depression |
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