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| MICA基因与系统性红斑狼疮关系的研究 | |
| 引用本文： | 班贵宏,褚嘉档,冒长峙,杨昭庆,许绍斌,初正韬,黄小琴,张思仲.MICA基因与系统性红斑狼疮关系的研究[J].中华医学遗传学杂志,2002,19(4):298-301. |
| 作者姓名： | 班贵宏 褚嘉档 冒长峙 杨昭庆 许绍斌 初正韬 黄小琴 张思仲 |
| 作者单位： | 1. 650118,昆明,中国医学科学院中国协和医科大学医学生物学研究所遗传室 2. 昆明医学院第二附属医院 3. 四川大学华西医院 |
| 基金项目： | 国家自然科学基金重大项目 (3999342 0 )，美国中华医学基金会 (98- 675)~~ |
| 摘 要： | 目的 明确云南汉族群体中主要组织相容性复合物Ⅰ类链相关基因A（major histocompatibility complex class I chian-related gene,MICA）基因与系统性红斑狼疮（systemic Iupus erythematosus,SLE）的关系。方法 应用STR扫描分型技术、聚合酶链反应－单链构象多态性和DNA双向序列测定，确定MICA基因第4、5外显子在云南汉族70例SLE患者和152名正常对照中的等位基因及其分布频率。结果 共发现MICA第5外显子5种等位基因和第4外显子10种等位基因，并确定了各自在病例组和对照组中的分布频率，表明MICA第4、5外显子各等位基因的分布频率在SLE病例组和对照组中差异无显著性。结论 云南汉族群体中MICA基因第4、5外显子的各等位基因与云南汉族系统性红斑狼疮无相关性。 |
| 关 键 词： | 主要组织相容性复合物Ⅰ类链相关基因A 云南汉族 系统性红斑狼疮 MICA SLE |
| 修稿时间： | 2001年6月29日 |
A study of the relationship between MICA gene and systemic lupus erythematosus |
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| BAN Guihong ,CHU Jiayou ,MAO Changzhi ,YANG Zhaoqing ,XU Shaobin ,CHU Zhengtao ,HUANG Xiaoqin ,ZHANG Sizhong ..A study of the relationship between MICA gene and systemic lupus erythematosus[J].Chinese Journal of Medical Genetics,2002,19(4):298-301. | |
| Authors: | BAN Guihong CHU Jiayou MAO Changzhi YANG Zhaoqing XU Shaobin CHU Zhengtao HUANG Xiaoqin ZHANG Sizhong |
| Institution: | Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan, 650118 P.R. China. chujy@public.km.yn.cn |
| Abstract: | OBJECTIVE: To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE). METHODS: The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing. RESULTS: Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene. CONCLUSION: Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans. |
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