Deep cerebral venous thrombosis in adults

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Deep cerebral venous thrombosis in adults

Objective To investigate the pathogenesis, clinical features, radiographic findings and th erapeutic outcomes of non-acute intracranial deep venous thrombosis in adults. Methods Five patients who presented with increased intracranial pressure were examined w ith computed tomography, magnetic resonance and angiography, diagnosed as having non-acute intracranial deep venous thrombosis, and treated with thrombolytic t herapy. They were reviewed retrospectively.Results There were 3 men and 2 women, aged from 22 to 49 years. Symptom duration ranged from 1 month to 7 months, and 4 of the 5 patients were associated with venous s inus thrombosis. Two patients developed cold and fever before the onset of dise ase, and 3 patients had no evident predisposing factors. After the infusion of thrombolytic and systemic anti-coagulant therapy, the neurological symptoms and signs of the patients were alleviated.Conclusions Digital subtraction angiography (DSA) is more sensitive and accurate than MRI on diagnosing intracranial deep venous thrombosis. It may play an important role in the assessment of the treatment of intracranial deep venous thrombosis. Thro mbolysis and anticoagulation of intracranial deep venous thrombosis appears to b e a safe and efficacious treatment not only in the acute stage but also in the n on-acute stage.