| Nestin expression and proliferation of ependymal cells in adult rat spinal cord after injury |
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| 引用本文： | 刘暌,王忠诚,王红云,张亚卓. Nestin expression and proliferation of ependymal cells in adult rat spinal cord after injury[J]. 中华医学杂志(英文版), 2002, 115(3): 339-341 |
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| 作者姓名： | 刘暌 王忠诚 王红云 张亚卓 |
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| 作者单位： | Liu K，Wang ZC，Wang HY and Zhang YZ |
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| 摘 要： | Ｔｅｒｍｉｎａｌｌｙｄｉｆｆｅｒｅｎｔｉａｔｅｄｎｅｕｒｏｎｓａｒｅｉｎｃａｐａｂｌｅｏｆｍｉｔｏｓｉｓ ,ａｎｄｃｏｍｐｅｎｓａｔｏｒｙｎｅｕｒｏｎａｌｐｒｏｄｕｃｔｉｏｎｈａｓｎｏｔｂｅｅｎｏｂｓｅｒｖｅｄｉｎａｎｙｍａｍｍａｌｉａｎｍｏｄｅｌｓｏｆｓｔｒｕｃｔｕｒａｌｂｒａｉｎｄａｍａｇｅ Ｐａｓｔｓｔｕｄｉｅｓｈａｖｅｓｕｇｇｅｓｔｅｄｔｈａｔｔｈｅｌａｃｋｏｆｎｅｕｒｏｎａｌｐｒｏｄｕｃｔｉｏｎｉｎｔｈｅａｄｕｌｔｍａｍｍａｌｉａｎｂｒａｉｎｒｅｆｌｅｃｔｅｄａｆｕｎｄａｍｅｎｔａｌｂｉ…
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| 关 键 词： | spinal cord injury · proliferation · neural stem cell |
Nestin expression and proliferation of ependymal cells in adult rat spinal cord after injury |
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| LIU Kui,WANG Zhongcheng,WANG Hongyun,ZHANG Yazhuo. Nestin expression and proliferation of ependymal cells in adult rat spinal cord after injury[J]. Chinese medical journal, 2002, 115(3): 339-341 |
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| Authors: | LIU Kui WANG Zhongcheng WANG Hongyun ZHANG Yazhuo |
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| Affiliation: | Beijing Neurosurgical Institute, Beijing 100050, China;Beijing Neurosurgical Institute, Beijing 100050, China;Beijing Neurosurgical Institute, Beijing 100050, China;Beijing Neurosurgical Institute, Beijing 100050, China |
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| Abstract: | Objective To determine cell proliferation and nestin expression in the ependyma of adu lt rat spinal cord after injury. Methods Rat spinal cord injury models were established by aneurysm clip compression, and nestin expression and proliferation of ependymal cells at different times were shown with pathological and immuno-histochemical staining.Results Ependymal cells adjacent to the injured site demonstrated a dramatic increase in nestin expression 24 hours after compression. Proliferating cell nuclear antig en was positive, and significant proliferation was observed after 7 days. Nesti n expression was down regulated as time went by. Conclusion Normally quiescent mature ependymal cells appear to revert to an embryonic state in response to spinal cord injury. |
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| Keywords: | spinal cord injury proliferation neural st em cell |
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