乳腺癌患者ST13、Hsp70、pS2、雌激素受体和孕激素受体表达及其与生存的关系

目的 研究乳腺癌患者ST13、Hsp70、pS2、雌激素受体（ER）和孕激素受体（PR）表达及其与生存关系。方法 选择1993至1994年间有完整随访资料和蜡块的乳腺癌患者45例，以免疫组织化学法检测ER、PR、pS2、Flsp70和ST13在乳腺癌组织中的表达及相关性分析；并进行Ka-plan-Meier生存率分析和COX生存分析。结果（1）本组乳腺癌组织中ER、pS2、PR、ST13和HspT0表达的阳性率依次分别为77．8％、68．9％、66．7％、64．4％和62．2％。其中ST13分别与ER、PR和pS2三者呈显著正相关性（分别为P＜0．01、P＜0．05和P＜0．05）。而ER与PR也呈非常显著的正相关性（P＜0．01）。（2）Kaplan-Meier生存率曲线及LogRank显著性检验发现，仅ST13和HspT0阳性者明显提高乳腺癌患者的5年生存率（P＜0．05）。COX生存分析也发现ST13和Flsp70阳性提高乳腺癌患者5年生存（P＜0．05）。结论 （1）ER、PR、pS2、ST13和Hsp70在乳腺癌组织中均高表达，其中ER与PR及ST13与ER、PR和pS2呈非常显著的正相关性。（2）Kaplan-Meier生存率分析和COX生存分析均提示ST13和Hsp70阳性者明显提高乳腺癌患者的5年生存率（P＜0．05）。

The expression of ER,PR,pS2,Hsp70 and ST13,and their interaction with survival in breast cancer patients

Objective To study the expression of ER,PR,pS2,Hsp70 and ST13,and their interaction with survival in breast cancer patients.Methods The expression of ER,PR,pS2,Hsp70 and ST13 was detected in 45 cases of breast cancer during 1993-1994 with follow-up data,and the Kaplan-Meier survival analysis and COX survival ananlysis were done.Results (1) The positive rates of ER,PR,pS2,Hsp70 and ST13 were 77.8%, 68.9%, 66.7%, 64.4% and 62.2%,respectively in this group.There was a positive correlation among ER,PR,pS2 and ST13,especially between ER and ST13 (P= 0.000),ER and PR (P= 0.000).(2) In Kaplan-Meier survival analysis and Log Rank test,only the patients with expression of ST13 and Hsp70 had the higher 5-year survival rate (P< 0.05),and also in the COX survival ananlysis model.Conclusion ER,PR,pS2,Hsp70 and ST13 are abundant in breast cancer.There are very close relationship among ER,PR,pS2 and ST13.But Hsp70 is the independent parameter.The expression of ST13 or Hsp70 can significantly increase the 5-year survival in single or multivariate survival analysis.