| 全反式维甲酸激活人肺腺癌细胞系GLC-82中-PIG-B高度同源基因-PIGB1 |
| |
| 引用本文： | 王雪皎,王秀琴,张睿,丁芳,郭明洲,刘芝华,于振涛,吴旻.全反式维甲酸激活人肺腺癌细胞系GLC-82中-PIG-B高度同源基因-PIGB1[J].癌症,1999,18(6):631-634. |
| |
| 作者姓名： | 王雪皎 王秀琴 张睿 丁芳 郭明洲 刘芝华 于振涛 吴旻 |
| |
| 作者单位： | 中国医学科学院中国协和医科大学肿瘤研究所细胞生物室分子肿瘤学国家重点实验室,北京,100021 |
| |
| 摘 要： | 目的：探讨全反式维甲酸（all-trans retinlic acid,ＡＴＲＡ）诱导肿瘤细胞分化的分子机制。方法：采用Ｓouthern和Ｎorthern杂交方法对本室用ＡＴＲＡ诱导人肺腺癌细胞ＧＬＣ－８２，经消减杂交所构建的cＤＮＡ消减文库ＰＩＧＢ１，该基因与人ＰＩＧ－Ｂ（phosphaidylinlsitol glycan of clmplementaion class Ｂ）基因高度同源，在多种胎儿组织中均有表达。结论：ＰＩＧＢ１基因可能参与ＡＴＲＡ诱导肿瘤细胞分化过程。
|
| 关 键 词： | 全反式维甲酸 肺腺癌 分化 |
| 文章编号： | 1000－467X(1999)－06－063－04 |
| 修稿时间： | 1999－03－09 |
PIGB1, a gene with highly homologous to PIG-B,up-regulated in human lung adenocarcinoma cell line GLC-82 treated by all-trans retinoic acid |
| |
| WANG Xue jiao,WANG Xiu qin,ZHANG Rui,et al..PIGB1, a gene with highly homologous to PIG-B,up-regulated in human lung adenocarcinoma cell line GLC-82 treated by all-trans retinoic acid[J].Chinese Journal of Cancer,1999,18(6):631-634. |
| |
| Authors: | WANG Xue jiao WANG Xiu qin ZHANG Rui |
| |
| Affiliation: | WANG Xue jiao,WANG Xiu qin,ZHANG Rui,et al. Department of Cell Biology,National Lab of Molecular Oncology,Cancer Institute,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100021,P.R.China$$$$ |
| |
| Abstract: | Objective:To explore the molecular mechanism of cancer cell differentiation induced by all trans retinoic acid (ATRA ). Methods:Southern and Norhtern hybridization methods were used to screen the cDNA subtractive library constructed from ATRA induced human lung adenocarcinoma cell line GLC 82 in our laboratory. After sequence analysis,RT PCR method was used to analyze the expression pattern in human fetal tissues. Results:PIGB1,a gene highly homologous to phosphatidylinositol glycan of complementation class B (PIG B),up regulated by ATRA,was cloned. PIGB1 expresses in various human fetal tissues. Conclusion:PIGB1 may be involved in differentiation of lung adenocarcinoma cell induced by ATRA. |
| |
| Keywords: | PIG-B PIGBI |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
