| Abstract: | Comorbidity remains an important scientific and practical medical problem especially in respect to such prevalent and socially significant diseases as arterial hypertension (AH) and ulcerative-erosive gastroduodenal lesions (UEGDL). In these diseases there are common etiological and pathogenetic factors reflecting syntropy of this combination. These factors include systemic vascular disorders, homeostatic alterations, immunological disturbances, mental diseases, metabolic syndrome, impairment of cellular membranes as a result of activation of lipid peroxidation, etc. Adequate therapy is essential in AH comorbidity with UEGDL. It should be directed not only to lowering of blood pressure and local pathogenetic factors (acidopeptic, infectious, vascular) but also predict pharmacological impact on both diseases and other risk factors to reduce probability of unfavourable outcomes, correct damaged mechanisms of adaptive regulation of the organism and improve quality of patients' life. Specificity of the comorbide course of AH and UEGDL should be considered to perform adequate treatment, goal-oriented prevention and prediction of complications. |
