Expression of mdr1, mrp and lrp genes in gastric carcinoma and their clinical significance |
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| Authors: | Zhongmin Liu Nanhai Shou Xihong Jiang |
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| Institution: | (1) Department of General Surgery, the first Affiliated Hospital, Shandong Medical University, #107 Wen-Hhua-Xi Road, 250012 Jinan, China;(2) Present address: Department of General Surgery, Taian Central Hospital, 271000 Taian, China |
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| Abstract: | Objective: To explore the expression of mdr1, multidrug resistance-associated protein (MRP) and lung resistance protein (LRP)
genes in human gastric cancer and their clinical significance. Methods: The mdr1 mRNA was assayed by RT-PCR, the MRP and LRP
were detected by flow cytometry. Results: The positive rate of mdr1 mRNA was 44.4% (12/27), and the mean MRP and LRP expression
were independent upon patient histologic type, nodal involvement, and TNM stage. The mdr1 mRNA expression in patients with
serosa invasion was 30.0% (6/20), much lower than that without serosa invasion (85.7%). Conclusion: The multidrug resistance
cells are present in primary gastric carcinomas prior to chemotherapy, and analysis of mdr1 gene, MRP, LRP may have guiding
significance in the treatment of gastric carcinoma. |
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| Keywords: | Stomach cancer Adenocarcinoma Drug resistance Multidrug resistance-associated protein Lung resistance protein |
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