| 离心造粒法和流化床包衣制备硫普罗宁肠溶微丸 |
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| 引用本文： | 蔡荣刚,王成润,金一. 离心造粒法和流化床包衣制备硫普罗宁肠溶微丸[J]. 江苏大学学报(医学版), 2011, 21(5): 443-445,448 |
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| 作者姓名： | 蔡荣刚 王成润 金一 |
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| 作者单位： | 浙江大学药学院,浙江,杭州,310058 |
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| 摘 要： | 目的:应用离心造粒法及流化床包衣制备硫普罗宁肠溶微丸,并对其性质进行考察.方法:采用国产离心造粒机制备硫普罗宁微丸,采用L9(34)正交设计实验优化工艺条件;用底喷流化床包衣设备,将微丸包肠溶衣,考察微丸的粉体学性质及不同包衣增重微丸的体外释放实验.结果:制得的硫普罗宁微丸圆整度好,大小均匀.20%包衣增重的微丸体外释...
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| 关 键 词： | 硫普罗宁 离心造粒 微丸 流化床包衣 体外释放度 |
Preparation of tiopronin pellets by centrifugation pelletizing and fluid bed coating technology |
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| CAI Rong-gang,WANG Cheng-run,JIN Yi. Preparation of tiopronin pellets by centrifugation pelletizing and fluid bed coating technology[J]. Journal of Jiangsu University Medicine Edition, 2011, 21(5): 443-445,448 |
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| Authors: | CAI Rong-gang WANG Cheng-run JIN Yi |
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| Affiliation: | CAI Rong-gang,WANG Cheng-run,JIN Yi(College of Pharmaceutical Science,Zhejiang University,Hangzhou Zhejiang 310058,China) |
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| Abstract: | Objective: To prepare tiopronin pellets by centrifugation pelletizing and bottom-spray fluid bed coating technology,and investigate the properties of the pellets.Methods: Tiopronin pellets were prepared using a domestic centrifugation pelletizing equipment.The optimal formulation was obtained by L9(34) orthogonal design.The pellets were enteric-coated using a fluid bed coating equipment.The micromeritics properties and in vitro dissolution of the pellets were investigated.Results: Tiopronin pellets prepared... |
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| Keywords: | tiopronin centrifugation pelletizing pellets fluid bed coating technology dissolution in vitro |
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