| PDGF-AB对人正常皮肤和增生性瘢痕成纤维细胞-胶原网收缩影响的差异 |
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| 引用本文： | 董茂龙,陈璧,徐明达,胡大海,韩军涛,姚庆君.PDGF-AB对人正常皮肤和增生性瘢痕成纤维细胞-胶原网收缩影响的差异[J].第四军医大学学报,2005,26(3):226-228. |
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| 作者姓名： | 董茂龙 陈璧 徐明达 胡大海 韩军涛 姚庆君 |
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| 作者单位： | 第四军医大学西京医院烧伤科,陕西,西安,710033;第四军医大学西京医院烧伤科,陕西,西安,710033;第四军医大学西京医院烧伤科,陕西,西安,710033;第四军医大学西京医院烧伤科,陕西,西安,710033;第四军医大学西京医院烧伤科,陕西,西安,710033;第四军医大学西京医院烧伤科,陕西,西安,710033 |
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| 摘 要： | 目的：研究血小板衍生生长因子(PDGF)—AB对人正常皮肤和增生性瘢痕成纤维细胞一胶原网(FPLC)收缩影响的差异，探讨PDGF—AB促进伤口愈合的作用机制及其在瘢痕增生中的作用．方法：取体外培养的人正常皮肤(NsFb)及增生性瘢痕成纤维细胞(HTsFb)，建立成纤维细胞—胶原网模型，比较PDGF—AB对两种成纤维细胞—胶原网收缩影响的差异．结果：PDGF—AB对两种成纤维细胞—胶原网收缩均有明显促进作用，且均呈剂量依赖性关系，但作用有差异．结论：PDGF—AB可能通过刺激伤口收缩促进创面愈合，同时可能在瘢痕挛缩性疾病中起重要作用。
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| 关 键 词： | 血小板衍生生长因子-AB 成纤维细胞 胶原 瘢痕 |
| 文章编号： | 1000-2790(2005)03-0226-03 |
| 修稿时间： | 2004年9月9日 |
Effect of PDGF-AB on contraction of human normal skin and hypertrophic scar fibroblast-populated collagen lattice |
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| DONG Mao-Long,CHEN Bi,XU Ming-Da,HU Da-Hai,HAN Jun-Tao,YAO Qing-Jun.Effect of PDGF-AB on contraction of human normal skin and hypertrophic scar fibroblast-populated collagen lattice[J].Journal of the Fourth Military Medical University,2005,26(3):226-228. |
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| Authors: | DONG Mao-Long CHEN Bi XU Ming-Da HU Da-Hai HAN Jun-Tao YAO Qing-Jun |
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| Institution: | DONG Mao-Long,CHEN Bi,XU Ming-Da,HU Da-Hai,HAN Jun-Tao,YAO Qing-Jun Department of Burn Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM: To study the effect of PDGF-AB on the contraction of human normal skin and hypertrophic scar fibroblast-populated collagen lattice and to investigate the mechanism by which PDGF-AB promotes wound healing and the effect of PDGF-AB in scar forming. METHODS: In vitro cultured human normal skin and hypertrophic scar fibroblasts (NsFb, HTsFb) were applied to measure the effect of PDGF-AB on the contraction of FPLC. RESULTS: PDGF-AB increased the contraction of NsFb and HTsFb-populated collagen lattice in a dose dependent manner, but it had stronger effects on HTsFb-populated collagen lattice. CONCLUSION: PDGF-AB may promote wound healing by stimulating the wound contraction, and PDGF-AB may also play some important roles in scar contracture. |
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| Keywords: | PDGF-AB fibroblast collagen cicatrix |
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