Chemoradiotherapy in tumours of the oesophagus and gastro-oesophageal junction |
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| Institution: | 1. Department of Radiotherapy, Academic Medical Center, Amsterdam, The Netherlands;2. Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands;1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;3. Department of Gastroenterology & Hepatology, Bankstown-Lidcombe Hospital, South Western Sydney Local Health Network, Sydney, New South Wales 2200, Australia;1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;1. Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;2. Department of Thoracic Surgery, Tumor Hospital, Xinjiang Medical University, Urumqi, China;1. Department of Radiation Therapy, Cangzhou Central Hospital, Cangzhou, China;2. Department of Endoscopic Professional, Cangzhou Central Hospital, Cangzhou, China |
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| Abstract: | Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10–15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT has changed the treatment intent from palliative to curative. Definitive CRT is a good alternative for radical surgery in responding patients with squamous cell carcinoma and those running a high risk of surgical morbidity and mortality. For patients with an out-of-field solitary locoregional recurrence after primary curative treatment, definitive CRT can lead to long term survival. |
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| Keywords: | Chemoradiotherapy Oesophageal cancer Gastro-oesophageal junction tumours Chemotherapy Radiotherapy |
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