Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis |
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| Affiliation: | 1. Academic Medical Center Amsterdam, Department of Gastroenterology & Hepatology, Netherlands;2. Academic Medical Center Amsterdam, Department of Surgery, Netherlands;1. Department of Gastroenterology and Gastrointestinal Surgery, Hvidovre Hospital, University of Copenhagen, Denmark;2. National Institute of Public Health, University of Southern Denmark, Denmark;1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran;3. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran;4. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord 34141, Iran;1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;3. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;4. Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, and Department of Veterans Affairs, Los Angeles, California;6. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii;5. Memorial Sloan Kettering Cancer Center, New York, New York;1. Department of Surgery, Radboud university medical center, Nijmegen, the Netherlands;2. Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, the Netherlands;3. Department of Gastroenterology and Hepatology, Gelderse Vallei Hospital, Ede, the Netherlands;4. Department of Intensive Care Medicine and Surgery, MUMC+, Maastricht, the Netherlands;5. Department of Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands;6. Department of Surgery, UMC Utrecht, Utrecht, the Netherlands;7. Department of Surgery, Leicester University Hospital, Leicester, United Kingdom;1. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;2. Department of Nutrition and Dietetics, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK;3. Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain |
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| Abstract: | Background/objectivesPatients with chronic pancreatitis (CP) are at risk of malnutrition due to malabsorption, pain and/or alcohol consumption. This can cause vitamin D insufficiency or deficiency, which is associated with osteoporosis and increased risks of fractures. We aimed to perform a meta-analysis to determine the prevalence of vitamin D insufficiency and deficiency in CP patients. Furthermore, we compared these results with healthy controls.MethodsWe performed a systematic review and meta-analysis on the literature by searching PubMed and EMBASE (January 2000–December 2015) on CP and vitamin D. Primary outcome was prevalence of vitamin D insufficiency (<75 nmoL/L) and deficiency (<50 nmoL/L) in CP patients. When available, data of CP patients were compared with healthy controls.ResultsNine studies were included in our meta-analysis, reporting on the prevalence of vitamin D insufficiency/deficiency in 465 patients (mean age 41 years (range 18–60), 81% male) and in 378 controls (mean age 40 years (range 18–67), 76% male). Pooled prevalence of vitamin D insufficiency and deficiency in CP patients was 83% and 65%, respectively. Calculated odds ratio (OR) of vitamin D insufficiency and deficiency between CP patients and controls was 1.34 (0.54–3.29) and 1.14 (0.70–1.85), respectively (p > 0.05).ConclusionThere is a high prevalence of vitamin D insufficiency and deficiency in CP patients. Nevertheless, there is no significant difference in prevalence of vitamin D insufficiency and deficiency compared to healthy controls. Further research should indicate the clinical relevance and consequences of these findings for clinical practice. |
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| Keywords: | Chronic pancreatitis Exocrine pancreatic insufficiency Prevalence Systematic review Vitamin D deficiency |
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