Familial non-medullary thyroid cancer: an update on the genetic and pathologic features |
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| Institution: | 1. Department of Obstetrics & Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;2. Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon-Si, Republic of Korea;3. Department of Obstetrics & Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;3. From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,;4. College of Pharmacology,;5. Department of Surgery, and;6. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109;1. Novartis Institutes for Biomedical Research, Emeryville, CA;;2. Department of Pediatrics and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA |
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| Abstract: | Well differentiated thyroid carcinoma is one of the most increasingly prevalent cancers, and while many are sporadic, some are inherited. These heritable thyroid cancers are grouped as familial non-medullary thyroid carcinoma (FNMTC) and represent approximately 5–10% of non-medullary thyroid carcinomas. While the group of FNMTC is quite heterogeneous, an ever increasing number of attributable genetic changes have been described. In addition to the classic, non-syndromic FNMTC there are also several well defined and characterized genetic syndromes with thyroid cancer as a component. This review will provide an update on the current molecular understanding of both syndromic and non-syndromic heritable thyroid cancer. |
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| Keywords: | follicular thyroid carcinoma genetics papillary thyroid carcinoma thyroid cancer |
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