Molecular Pathology: Predictive,Prognostic, and Diagnostic Markers in Lymphoid Neoplasms |
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| Affiliation: | 1. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;2. Department of Pathology, Weill Cornell Medical College, 525 East 68th Street, Mailbox #79, F-540, New York, NY 10065, USA;1. Department of Pathology, University of California, San Diego, 200 West Arbor Drive, La Jolla, CA 92103, USA;2. Division of Anatomic Pathology, Department of Pathology, University of California, San Diego, 9500 Gilman Drive, MC 0612, La Jolla, CA 92093, USA;1. Department of Pathology, St. Jude Children''s Research Hospital, Memphis, TN 38105, USA;2. Department of Computational Biology, St. Jude Children''s Research Hospital, Memphis, TN 38105, USA;3. Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada;4. Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada;5. Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;6. University of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87106, USA;7. Cytogenetics Shared Resource, St. Jude Children''s Research Hospital, Memphis, TN 38105, USA;8. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;9. Montefiore Medical Center, Bronx, NY 10467, USA;10. Department of Hematology, Shaare Zedek Medicak Center, Jerusalem 910310, Israel;11. Department of Oncology, St. Jude Children''s Research Hospital, Memphis, TN 38105, USA;12. The Research Institute at Nationwide Children''s Hospital, Columbus, OH 43205, USA;13. Department of Pediatrics and the Helen Diller Family Cancer Center, University of California, San Francisco, CA 94115, USA;14. Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA;15. Cancer Research Foundation of New York, Bronx, NY 10514, USA;16. Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA;17. Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA;18. Department of Pediatrics and Center for Childhood Cancer Research, The Children''s Hospital of Philadelphia, Philadelphia, PA 19104, USA |
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| Abstract: | Lymphoid neoplasms show great diversity in morphology, immunophenotypic profile, and postulated cells of origin, which also reflects the variety of genetic alterations within this group of tumors. This review discusses many of the currently known genetic alterations in selected mature B-cell and T-cell lymphoid neoplasms, and their significance as diagnostic, prognostic, and therapeutic markers. Given the rapidly increasing number of genetic alterations that have been described in this group of tumors, and that the clinical significance of many is still being studied, this is not an entirely exhaustive review of all of the genetic alterations that have been reported. |
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| Keywords: | Lymphoma Mutation Molecular marker Genetics B cell T cell Targeted therapy |
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