三白草地上部分化学成分研究

目的 研究三白草Saururuschinensis地上部分的化学成分。方法 采用超临界CO2萃取，硅胶、ODS、MCIGel柱色谱和半制备高效液相色谱等色谱技术进行系统的分离纯化，根据光谱数据和理化性质进行化合物的结构鉴定。结果 从三白草地上部分的超临界CO2萃取物中分离得到15个化合物，分别鉴定为2,3-二甲基-1,4-二(3,4,5-三甲氧基苯基)-1,4-丁二酮（1）、asperphenamate(2)、rel-(7S,8S,7’R,8’R)-3,3’,4,4’,5,5’-六甲氧基-7-O-7’,8.8’-木脂素（3）、常春藤皂苷元（4）、schisandlignans C(5)、樟叶素（6）、4-羟基-5-甲基己烷-5-内酯（7）、异黑麦草内酯（8）、perseal B(9)、myrisfragransin(10)、heteroplexisolide E(11)、curcasinlignan C(12)、去氢催吐萝芙木醇（13）、黑麦草内酯（14）和三白草二萜E(15)。结论 化合物15为新化合物，化合物1为新的天然产物；除化合物3、6、13外均为首次从该植物中分离得到。

Chemical constituents from aerial parts of Saururus chinensis

Objective To study the chemical constituents from aerial part of Sanbaicao Saururus chinensis (Lour.) Baill.]. Methods In this study, after supercritical CO₂ extracting, the chemical constituents were isolated by various chromatographic methods, such as silica gel, ODS, MCI and semi-preparation HPLC, and their structures were identified by spectral data and physicochemical property. Results Fifteen compounds were isolated and identified as 2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane-1,4-dione (1), asperphenamate (2), rel-(7S,8S,7''R,8''R)-3,3'',4,4'',5,5''-hexamethoxy-7-O-7'',8.8''-lignan (3), hederagenin (4), schisandlignans C (5), polysyphorin (6), 4-hydroxy-5-methylhexan-5-olide (7), isololiolide (8), perseal B (9), myrisfragransin (10), heteroplexisolide E (11), curcasinlignan C (12), dehydrovomifoliol (13), loliolide (14) and sauruditerpene E (15). Conclusion Compound 15 is a new compound, compound 1 is a new natural compound, and the others are isolated from this plant for the first time except compounds 3, 6 and 13.