Secretin-stimulated magnetic resonance imaging/magnetic resonance cholangiopancreatography for the detection of chronic pancreatitis: A meta-analysis |
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| Affiliation: | 1. University of Naples Federico II, Agricultural Economics and Policy Department, Via Università, 96-80055 Portici, NA, Italy;2. University of Messina, Dipartimento di Economia, Piazza Pugliatti, 1-98122 Messina, Italy;1. Research Institute on Aging, The New Jewish Home, New York, NY;2. Department of Psychology, Fordham University, Bronx, NY;3. The New Jewish Home, New York, NY;1. Hunan Provincial Key Laboratory of High Efficiency and Precision Machining of Difficult-to-Cut Material, Hunan University of Science and Technology, Xiangtan 411201, China;2. College of Mechanical and Electrical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China;1. ICU Center, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China;2. Department of Respiratory, Anhui Provincial Hospital, No. 17 Luyang Road, Hefei 230011, Anhui, China;3. Department of Pediatrics, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China;4. Department of Urology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Furong, Changsha 410011, Hunan, China |
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| Abstract: | ObjectiveTo evaluate the diagnostic accuracy of secretin-stimulated magnetic resonance imaging/magnetic resonance cholangiopancreatography (S-MRI/MRCP) as noninvasive modalities in detecting chronic pancreatitis (CP).MethodsA systematic literature search in the PubMed, EMBASE, Web of Science, Cochrane, and Chinese Biomedical Literature Databases to identify relevant original studies. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (version 2). Study data were independently extracted to calculate sensitivity and specificity, as well as areas under summary receiver operating characteristic curves (AUCs), and to test for heterogeneity and the threshold effect.ResultsThe sample comprised 11 studies including 180 patients with CP and 340 patients without CP. Pooled sensitivity and specificity were 0.72 (95% confidence interval [CI] 0.65–0.78) and 0.87 (95% CI 0.83–0.90), respectively. Pooled positive and negative likelihood ratios were 4.99 (95% CI 2.59–9.61) and 0.32 (95% CI 0.19–0.54), respectively. The diagnostic odds ratio was 23.31 (95% CI 7.50–72.44). The AUC and Q1 index were 0.8631 and 0.7937, respectively. Publication bias was absent (P = 0.64).ConclusionsS-MRI/MRCP had low sensitivity and moderately high specificity for the detection of CP. Large-scale, quality-controlled, prospective studies are needed to verify the diagnostic accuracy of these modalities. |
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| Keywords: | Magnetic resonance imaging Magnetic resonance cholangiopancreatography Chronic pancreatitis Secretin Meta-analysis Diagnostic accuracy ADC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" apparent diffusion coefficient AUC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" area under the summary receiver operating characteristic curve CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" confidence interval CP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" chronic pancreatitis DW" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" diffusion-weighted ERCP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" endoscopic retrograde cholangiopancreatography FN" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" false negative FP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" false positive S-MRI/MRCP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" secretin-stimulated magnetic resonance imaging/magnetic resonance cholangiopancreatography SROC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" summary receiver operating characteristic curve TN" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" true negative TP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" true positive |
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