| 体外模型在中药代谢研究中的应用 |
| |
| 引用本文： | 王莎,刘斯琪,丁鹏敏,庞月笙,陶志,王如峰.体外模型在中药代谢研究中的应用[J].药学进展,2020(2):119-132. |
| |
| 作者姓名： | 王莎 刘斯琪 丁鹏敏 庞月笙 陶志 王如峰 |
| |
| 作者单位： | 北京中医药大学生命科学学院 |
| |
| 基金项目： | 国家重点研发计划(No.2018YFC1704500)。 |
| |
| 摘 要： | 体内代谢研究对阐明中药药效物质基础及作用机制有重要意义。体外模型由于其替代、简化和精准的特点,已成为中药体内代谢研究的重要手段之一。综述药物体内过程研究中常用的体外模型及其特点,并总结其在中药代谢研究中的应用概况,以期为中药成分代谢研究提供理论和方法学参考。
|
| 关 键 词： | 体外模型 代谢 中药 应用 |
Application of in Vitro Models in Metabolism of Traditional Chinese Medicines |
| |
| WANG Sha,LIU Siqi,DING Pengmin,PANG Yuesheng,TAO Zhi,WANG Rufeng.Application of in Vitro Models in Metabolism of Traditional Chinese Medicines[J].Progress in Pharmaceutical Sciences,2020(2):119-132. |
| |
| Authors: | WANG Sha LIU Siqi DING Pengmin PANG Yuesheng TAO Zhi WANG Rufeng |
| |
| Institution: | (School of Life Sciences,Beijing University of Chinese Medicine,Beijing 102488,China) |
| |
| Abstract: | The study of metabolism is of great significance to the clarification of effective substances of traditional Chinese medicines(TCMs) and their mechanisms of action. Due to the characteristics of replacement, reduction and refinement, in vitro experimental models have become one of the important measures for in vivo metabolic studies. The in vitro models commonly used in the study of in vivo processes of drugs and their characteristics are reviewed, and their application in metabolic study of TCMs is summarized, in an attempt to provide theoretical and methodological references for the study of metabolism of TCMs. |
| |
| Keywords: | in vitro model metabolism traditional Chinese medicine application |
| 本文献已被 维普 等数据库收录！ |
|
