A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer |
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Affiliation: | 1. Department of Endocrinology and Diabetes, 251 Hellenic Air Force General Hospital, 3 Kanellopoulou St., 11525, Athens, Greece;2. Department of Pathophysiology, National University of Athens, 75 Mikras Asias St., 11527, Athens, Greece;3. Department of Endocrinology, 424 Military Hospital, 3 Gr. Lambraki St., 54638, Thessaloniki, Greece;4. REA Maternity Hospital, 383 A. Singrou Ave., P. Faliro, 17564, Athens, Greece |
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Abstract: | BackgroundK-ras codon 12 mutation is one of the earliest genetic changes in the development of pancreatic cancer (PC) and accurate detection of K-ras mutations is gaining increasing attention in the field of molecular diagnosis.MethodsOriginal research articles which evaluated the diagnostic accuracy of K-ras mutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic curve analysis was used to summarize the overall test performance.ResultsWe assessed 16 studies from 15 published articles. The pooled sensitivity and specificity were 59% (95%CI: 54%–64%) and 87% (95%CI: 84%–89%), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.13 (95%CI: 2.73–6.25) and 0.42 (95%CI: 0.32–0.56), respectively, and the pooled diagnostic odds ratio was 13.66 (95% CI: 7.25–25.74).ConclusionsOur results indicate that the analysis of K-ras mutations in pancreatic juice has a considerable diagnostic value in PC. Further studies with rigorous design, large sample size, and multi-regional co-operation are needed. |
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Keywords: | Diagnostic accuracy Meta-analysis Pancreatic cancer Pancreatic juice Molecular marker |
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