HIV co-receptor inhibitors as novel class of anti-HIV drugs |
| |
Authors: | Schols Dominique |
| |
Institution: | Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Dominique.schols@rega.kuleuven.be |
| |
Abstract: | Entry inhibitors constitute a new class of drugs to treat infection by human immunodeficiency virus type 1 (HIV-1). The first member of this class, enfuvirtide, previously known as T-20 and targeting gp41, has now been licensed for therapeutic use. Several other entry inhibitors are in various stages of pre-clinical or clinical development. In this review we focus on the chemokine receptor inhibitors targeting CCR5 and CXCR4 that are the main HIV co-receptors for viral entry. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|