HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish |
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| Authors: | Ross Owen A Curran Martin D Rea I Maeve Hyland Paul Duggan Orla Barnett Christopher R Annett Kathryn Patterson Chris Barnett Yvonne A Middleton Derek |
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| Affiliation: | Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK. owenaross@hotmail.com |
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| Abstract: | Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-alpha and G+252A TNF-beta), associated with increased TNF-alpha production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide. |
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| Keywords: | HLA TNF Polymorphism Immunosenescence |
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