| PREVALENCE OF ANTIBODY TO CIRCUMSPOROZOITE PROTEIN REPEATS AND CHARACTERIZATION OF PlASMODIUM VIVAX IN HUBEI PROVINCE, CHINA |
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| 引用本文： | 严继舟,张绍清,徐博钊. PREVALENCE OF ANTIBODY TO CIRCUMSPOROZOITE PROTEIN REPEATS AND CHARACTERIZATION OF PlASMODIUM VIVAX IN HUBEI PROVINCE, CHINA[J]. 中国病原生物学杂志, 1998, 0(4) |
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| 作者姓名： | 严继舟 张绍清 徐博钊 |
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| 作者单位： | 湖北省医学科学院寄生虫病研究所 |
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| 摘 要： | 收集湖北省间日疟现症病人、无症状病人及复发病人滤纸血，按ＥＬＩＳＡ法检测抗间日疟原虫环子孢子蛋白（ＣＳＰ）Ⅰ型（ＧＤＲＡＤＧＱＰＡ）、Ⅱ型（ＡＮＧＡＧＮＱＰＧ）和Ⅲ型（“Ｐ．ｖｉｖａｘ－ｌｉｋｅ”）（ＡＰＧＡＮＱＥＧＧＡＡ）重复体抗体。结果发现８３例受检血样中有３２例至少存在１型抗体，其中有Ⅰ型抗体的２７例、Ⅱ型抗体的５例、Ⅲ型抗体的１６例，包括两型混合感染的１０例和三型混合感染的４例。但只有Ⅰ型能被ＰＣＲ－探针确认。所收集的４份湖北间日疟病人全血中，虽然无１例检测到抗重复体抗体，但有３例被ＰＣＲ－探针确定为Ｉ型ＣＳＰ间日疟原虫单纯感染。本文还首次注意到间日疟原虫复发与Ⅰ型抗ＣＳＰ重复体ＩｇＧ抗体水平相关，并认为是休眠体刺激的结果。
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| 关 键 词： | 间日疟原虫 环子孢子蛋白 免疫 复发 |
PREVALENCE OF ANTIBODY TO CIRCUMSPOROZOITE PROTEIN REPEATS AND CHARACTERIZATION OF PlASMODIUM VIVAX IN HUBEI PROVINCE, CHINA |
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| Yan Jizhou Zhang Shaoqing Xu Bozhao D. Carucci A. Witney R. Webber D. C. Warhurst Institute of Parasitic Diseases,Hubei Academy of Medical Sciences. PREVALENCE OF ANTIBODY TO CIRCUMSPOROZOITE PROTEIN REPEATS AND CHARACTERIZATION OF PlASMODIUM VIVAX IN HUBEI PROVINCE, CHINA[J]. Journal of Pathogen Biology, 1998, 0(4) |
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| Authors: | Yan Jizhou Zhang Shaoqing Xu Bozhao D. Carucci A. Witney R. Webber D. C. Warhurst Institute of Parasitic Diseases Hubei Academy of Medical Sciences |
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| Affiliation: | Wuhan 430070 |
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| Abstract: | |
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| Keywords: | Plasmodium vivax circumsporozoite protein immunity relapse |
| 本文献已被 CNKI 等数据库收录！ |
