Dynamic functional connectivity in temporal lobe epilepsy: a graph theoretical and machine learning approach |
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Authors: | Fallahi Alireza Pooyan Mohammad Lotfi Nastaran Baniasad Fatemeh Tapak Leili Mohammadi-Mobarakeh Neda Hashemi-Fesharaki Seyed Sohrab Mehvari-Habibabadi Jafar Ay Mohammad Reza Nazem-Zadeh Mohammad-Reza |
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Institution: | 1.Biomedical Engineering Department, Engineering Faculty, Shahed University, Tehran, Iran ;2.Departamento de Fsica, Universidade Federal de Pernambuco, Recife, PE 50670-901, Brazil ;3.Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran ;4.Department of Biostatistics, School of Public Health, Hamadan University of Medical Science, Hamadan, Iran ;5.Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Science, Hamadan, Iran ;6.Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran ;7.Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran ;8.Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; |
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Abstract: | Purpose Functional magnetic resonance imaging (fMRI) in resting state can be used to evaluate the functional organization of the human brain in the absence of any task or stimulus. The functional connectivity (FC) has non-stationary nature and consented to be varying over time. By considering the dynamic characteristics of the FC and using graph theoretical analysis and a machine learning approach, we aim to identify the laterality in cases of temporal lobe epilepsy (TLE). MethodsSix global graph measures are extracted from static and dynamic functional connectivity matrices using fMRI data of 35 unilateral TLE subjects. Alterations in the time trend of the graph measures are quantified. The random forest (RF) method is used for the determination of feature importance and selection of dynamic graph features including mean, variance, skewness, kurtosis, and Shannon entropy. The selected features are used in the support vector machine (SVM) classifier to identify the left and right epileptogenic sides in patients with TLE. ResultsOur results for the performance of SVM demonstrate that the utility of dynamic features improves the classification outcome in terms of accuracy (88.5% for dynamic features compared with 82% for static features). Selecting the best dynamic features also elevates the accuracy to 91.5%. ConclusionAccounting for the non-stationary characteristics of functional connectivity, dynamic connectivity analysis of graph measures along with machine learning approach can identify the temporal trend of some specific network features. These network features may be used as potential imaging markers in determining the epileptogenic hemisphere in patients with TLE. |
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