2型糖尿病合并冠心病危险因素的临床研究

目的：探讨2型糖尿病（T2DM）患者导致冠心病（CHD）的危险因素.方法：将已确证为T2DM的85例患者,根据其是否并发CHD分为2组,其中单纯T2DM组44例,T2DM并发CHD组41例.了解并检测2组患者性别、年龄、体质量、病程、体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、血糖（FBG、P2BG）、胰岛素（FINS、PINS）、糖化血红蛋白（HbA1c）、胆固醇（TC、HDL-C、LDL-C、VLDL-C）、甘油三酯（TG）、血尿酸（UA）、胰岛素抵抗指数（HOMA-IR）和24 h微量白蛋白排泄率（UAE）、纤维蛋白原（FIB）、C-反应蛋白（S-CRP）及下肢动脉狭窄程度.结果：（1）2组在HbA1c、FBG、TG、TC、HDL-C、FINS、UMA、PINS、FIB、S-CRP方面差异无统计学意义（P＞0.05）.（2）2组在病程、BMI、SBP、DBP、P2BG、LDL-C、UA、HOMA-IR、P2BG/FBG方面差异有统计学差异（P＜0.05）.结论：病程、BMI、DBP、P2BG、LDL-C、HOMA-IR是T2DM并发CHD的高危临床因素,必须予以早期防治.

Clinical Study on the Risk Factors in Type 2 Diabetics Combined with Coronary Heart Disease

Objective: To explore the risk factors in type 2 diabetics combined with coronary heart disease. Methods: Eighty-five patients with type 2 diabetes mellitus were divided into diabetes combined with coronary heart disease group (41 cases) and simple diabetes group (44 cases). Data of gender, age, weight, duration, BMI, SBP, DBP, FBG, P2BG, FINS, PINS, HbA1c, TC, HDL-C, LDL-C, VLDL-C, TG, UA, HOMA-IR, UAE, FIB, S-CRP and strictured degree of low extremity artery in the two groups were compared and analyzed. Results:(1) There was no significant difference in HbA1c, FBG, TG, TC, HDL-C, FINS, UMA, PINS, FIB and S-CRP between two groups (P > 0.05). (2) There was a significant difference in duration, BMI, SBP, DBP, P2BG, LDL- C, UA, HOMA-IR and P2BG/FBG between two groups (P < 0.05). Conclusion: The risk factors in type 2 diabetics combined with coronary heart disease include duration, BMI, DBP, P2BG, LDL-C, HOMA-IR and P2BG/FBG. Type 2 diabetics combined with coronary heart disease should be treated as early as possible.