| 红芪多糖和黄芪多糖的免疫调节作用 |
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| 引用本文： | 毛小娟,王军志,王凤连.红芪多糖和黄芪多糖的免疫调节作用[J].中国药理学通报,1989(6). |
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| 作者姓名： | 毛小娟 王军志 王凤连 |
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| 作者单位： | [1]兰州医学院微生物学教研室 [2]兰州医学院药理学教研室 [3]中国医学科学院阜外医院临床免疫研究室 兰州 |
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| 摘 要： | 红芪多糖(RHPS)和黄芪多糖(APS)对正常小鼠和免疫抑制小鼠的免疫功能有影响.实验表明RHPS和APS均能增强小鼠腹腔巨噬细胞吞噬功能,并能完全纠正PDS的抑制作用;能促进体内淋巴细胞转化,并能使ANAE阳性淋巴细胞显著增多,对CY或PDS所致的细胞免疫功能低下有显著的纠正作用。家兔外周血淋巴细胞体外培养结果表明,RHPS或APS 1～100mg/L对PHA 50mg/L刺激淋巴细胞增生的作用无显著影响。RHPS对正常小鼠血浆cAMP水平无明显影响,但与PDS合用时可使血浆cAMP水平显著高出对照组和单用PDS组。
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| 关 键 词： | 红芪 黄芪 多糖 巨噬细胞 淋巴细胞 cAMP |
EFFECTS OF RADIX HEDYSARI POLYSACCHARIDE (RHPS) & ASTRAGALI POLYSACCHARIDE (APS) ON IMMUNE FUNCTIONS |
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| Abstract: | The effects of RHPS & APS on immune function in normal mice and immunosuppressed mice were studied. The results showed that RHPS and APS enhanced not only the phagocytosis of peritoneal mac-rophages in normal mice, but also antagonized completely the immun- Osuppresslve effect of prednisoione. RHPS and APS increased both the lymphocyte transformation rate induced by PHA and ANAE+ rate in normal mice, and antagonized also the suppressive effects of GY or PDS. No significant influence was found on the proliferation of rabbit lymphocyter treated with PHA in vitro. It seems that no obvious difference of effect was found on immune function between RHPS and APS. |
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| Keywords: | Radix Hedysari Astragalus membranaceus Polysaccha-ride Phagocytosis Lymphocyte cAMP |
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