| 趋化因子受体与肿瘤转移 |
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| 引用本文： | 薛同春,叶胜龙. 趋化因子受体与肿瘤转移[J]. 国外医学(肿瘤学分册), 2006, 0(10) |
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| 作者姓名： | 薛同春 叶胜龙 |
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| 作者单位： | 复旦大学肝癌研究所中山医院癌变与侵袭原理教育部重点实验室，复旦大学肝癌研究所中山医院癌变与侵袭原理教育部重点实验室 |
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| 摘 要： | 目前认为肿瘤细胞转移和淋巴细胞迁移具有相似机制,但趋化因子及其受体参与肿瘤转移的机制尚未完全阐明。由于其在肿瘤细胞器官选择性转移中的重要作用,趋化因子受体有希望成为肿瘤治疗的靶标并具有预后价值。现综述趋化因子受体与肿瘤侵袭和转移的研究进展。
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| 关 键 词： | 趋化因子 受体 趋化因子 肿瘤转移 |
Chemokine receptor and cancer metastasis |
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| XUE Tong-chun. Liver Cancer Institute,Zhongshan Hospital of Fudan University,Shanghai ,China. Chemokine receptor and cancer metastasis[J]. Foreign Medical Sciences (Cancer Section), 2006, 0(10) |
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| Authors: | XUE Tong-chun. Liver Cancer Institute Zhongshan Hospital of Fudan University Shanghai China |
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| Affiliation: | XUE Tong-chun. Liver Cancer Institute,Zhongshan Hospital of Fudan University,Shanghai 200032,China |
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| Abstract: | Recent edivence indicates that chemokine receptors,particularly CXCR4,may overex-press in some tumor tissues and metastatic tissues. The mechanisms which chemokine and their receptors participate in tumor metastasis are not understand completely although many researchers believe metastasis of tumor cells and lymphocyte share the similar mechanisms. Chemokine receptors may become the hopeful targets in tumor therapy and have merits of prognosis because of their critical roles in tumor metastasis to specific organs. This review will address mainly the advancement in the relationship between chemokine receptors expressions and tumors metastasis, the corresponding mechanisms and potential merits in therapy and prognosis in recent years. |
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| Keywords: | Chemokines Receptors chemokine Neoplasm metastasis |
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