| 重组人造血生长因子对抗白血病药物作用的影响 |
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| 引用本文： | 张晓晖,王椿,乔振华,左连富. 重组人造血生长因子对抗白血病药物作用的影响[J]. 山西医科大学学报, 1998, 0(1) |
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| 作者姓名： | 张晓晖 王椿 乔振华 左连富 |
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| 作者单位： | 山西医科大学第二临床医学院血液内科，河北省肿瘤研究所 |
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| 摘 要： | 采用流式细胞仪及ＩＮＴ细胞毒检测，研究造血生长因子（ｒｈＨＧＦ）对抗白血病药物细胞毒性的影响，并探讨ＨＧＦ与化疗药物联合应用的作用机理。研究结果表明：３种抗白血病药物柔红霉素（ＤＮＲ）、三尖杉酯碱（Ｈ）、足叶乙甙（ＶＰ１６）对白血病细胞敏感性存在较大差异；ＧＭＣＳＦ、ＩＬ３均能增加ＶＰ１６、ＤＮＲ对白血病细胞的杀伤作用；ＧＭＣＳＦ能提高Ｈ的细胞毒性作用，而对正常骨髓细胞，３种ｒｈＨＧＦ均不能增加３种化疗药物的细胞毒性
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| 关 键 词： | 造血生长因子 白血病.髓母细胞性 三尖杉酯碱类 柔红霉素 |
Effects of hematopoietic growth factor on the anti leukemia drugs to acute myeloid leukemia cells in vitro |
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| Zhang Xiaohui,Wang Chun,Qiao Zhenhua et al. Effects of hematopoietic growth factor on the anti leukemia drugs to acute myeloid leukemia cells in vitro[J]. Journal of Shanxi Medical University, 1998, 0(1) |
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| Authors: | Zhang Xiaohui Wang Chun Qiao Zhenhua et al |
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| Abstract: | To explore whether rhHGF and chemotherpeutic drugs combined treatment is helpful to killing more AML cells,an in vitro study on the combined effects of G CSF, GM CSF or IL 3 plus the chemotherapeutic drugs(DNR VP 16 or H)on the proliferation and cytotoxicity of blasts was carried out in AML patient and in normal bone marrow mononuclear cells(NBMMC).NBMMC from 11 healthy volunteers and AML blasts from 23 patients were incubated for 48h with HGF plus antileukemic drug.The drug sensitivity showed marked variation from case to case. The results showed enhancement of the cytotoxicity of DNR,VP 16 by GM CSF or IL 3. The results suggest significant enhancement of the H cytotoxicity for the AML samples by GM CSF.However,none of the HGF significantly effects the drug cytotoxicity of NBMMC. |
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| Keywords: | hematopoietic growth factor leukemia myeloblastic etoposide harringtonines daunorubicin |
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